Spotlight on Young Researchers: Charles de Bourcy

 

Charles de Bourcy decided to become a researcher on human health when he realised the human body is not invincible. After completing his undergraduate studies at University of Oxford, the Luxembourg national secured one of the most prestigious scholarships in the world and embarked on a PhD at Stanford University. Now in the final year of this PhD in Applied Physics, Charles is taking his first steps towards his goal of building technologies to help ease the burden of global disease.

Charles de Bourcy’s job in his PhD has been to try to find aspects of the human immune system that can be engineered to prevent or treat life-threatening diseases.

“My PhD projects focus on how immune cells can go wrong in old age, how they can be affected by immunotherapy for systemic sclerosis, and how we might prevent cancer-fighting cells from falling into a dysfunctional ‘exhausted’ state”, Charles explains.

Charles adds that this involves using the latest advances in genomics technology, combined with high-performance computing and quantitative analytics.

“Early on, a lot of time might be spent preparing blood samples for DNA sequencing, which means pipetting reagents. Later on, I spend most of my time coding to carry out computational analysis. In the afternoons, I often meet with the collaborators to discuss progress or learn about advances from other research groups. In the final phase of a project, I spend my days writing and preparing figures for publication.”

“I was drawn to the profound impact a researcher can have”

Charles explains his passion for research was triggered by the realisation that the human body is not invincible – that there are infectious diseases, cancers, autoimmune diseases and more that still have extremely limited treatment options.

“This feeling of helplessness pushed me to work on problems in human health. I was drawn to the profound impact the work of a researcher can have: a single discovery can change the paradigm for how an entire class of diseases are handled.

“For example, synthetic biology has enabled engineered immune cells against tumors, which have the potential to improve outcomes for a whole range of different cancers.

“Part of the fun is that such breakthroughs often happen in indirect ways — there’s this saying that the light bulb wasn’t invented by someone trying to make a better candle.”

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable”

In terms of what Charles wants to achieve as a scientist, he explains that he wants to help reduce the global disease burden, by building technologies that enable diseases to be treated – or prevented – in the best possible way:

“My first step in this endeavor has been to develop tools that allow previously impenetrable aspects of immunology to be measured quantitatively.

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable – advances in genomics, image processing and machine learning could be used to great effect in medicine, particularly if leveraged at a large scale.

“For example, surveys of immune repertoires and viral evolution across the globe could lead to more efficacious vaccine development and allow epidemics to be managed better, before they develop into catastrophic pandemics.”

Charles left Luxembourg for his undergraduate studies at the University of Oxford in the UK, before moving to Stanford University in California for his PhD. Even though Charles has been away for some years, he has been keeping an eye on the research landscape in Luxembourg for his future scientific plans:

“I have been following the development of Luxembourg’s research infrastructure with excitement. The country is pouring a lot of resources into expanding its research activity, making it a very attractive place to launch ambitious projects.”

Charles is now finishing up his PhD in Applied Physics at Stanford University. Charles’ PhD was funded by the International Fulbright Science & Technology Award and by the Melvin and Joan Lane Stanford Graduate Fellowship.

Meeting Nobel Prize winners

Charles was one of 400 early-career scientists selected to attend 2015 Lindau Nobel Laureate Meeting, with his attendance sponsored by the FNR – read an interview with Charles about the experience.

Charles at the 2015 Lindau Nobel Laureate Meeting, here with Françoise Barré-Sinoussi, 2008 recipient of the Nobel Prize in Physiology or Medicine for the discovery of HIV.
Charles de Bourcy

About Spotlight on Young Researchers

Spotlight on Young Researchers is an FNR initiative to highlight early career researchers across the world who have a connection to Luxembourg. This article is the 17th in a series of around 25 articles, which will be published on a weekly basis. You can see more articles below as and when they are published.

Spotlight on Young Researchers: Pier Mario Lupinu

When one thinks of banks and financial institutions, the word ‘research’ may not come to mind. However, research has much to offer these institutions, for example new tools to help with delivering critical services. As part of his PhD at the University of Luxembourg, Italian national Pier Mario Lupinu researches issues related to post-resolution in banking and finance.

Spotlight on Young Researchers: An algorithm to allocate satellite resources

When the first satellite was launched in the 1950s, earth orbit was a lonely place. Since then, more than 11,000 satellites have been launched into space and over 3,000 are still in operation. Estimates suggest an exponential increase in satellites in the next years, creating a challenge for the effective allocation of the needed bandwidth and power. Researchers are developing algorithms to more effectively allocate the resources where and when they are needed.

Spotlight on Young Researchers: Understanding the impact climate change has on crop-threatening insects

A type of insect known as whitefly spreads plant viruses and has devastating effects on the vegetables that we depend on and thanks to climate change their negative impact on agriculture is set to increase in the future. Current methods to protect crops depend on delicate relationships between whiteflies and their natural enemies, our crops, and microbial communities, a delicate balance threatened by climate change. Researchers are working with a ‘climate in the lab’ to get a better understanding of what could happen, with the ultimate goal to generate solutions to protect food security.

Spotlight on Young Researchers: The human gut microbiome and the clues it holds

Research is steadily painting a picture revealing the significance the human gut microbiome plays in health and disease. From gastrointestinal tract disorders to the beginnings and treatment of Parkinson’s disease and beyond, the gut microbiome is a treasure trove of clues for researchers. We speak to three women in science – a biomedical scientist, a microbiologist and a bioscience engineer – about organs-on-chips and restoring an imbalanced microbiome.

Spotlight on Young Researchers: The historical relationship between the European Community and the Soviet Union

As war rages in Ukraine, the topic PhD candidate Claude Ewert has been researching for the past three years is perhaps more relevant now than ever: the relationship between the European Community and the Soviet Union. The historian is gathering valuable information on the EC’s early foreign policy and the obstacles that had to be overcome to try to make the Community speak with one voice.

Spotlight on Young Researchers: Bella Tsachidou

Excessive use of fertilisers in agriculture has led to nitrogen pollution, and calls for bio substitutes are getting louder. PhD candidate Bella Tsachidou from Luxembourg Institute of Science and Technology (LIST) gathers scientific evidence on the benefits of biogas residues and their suitability as biofertilisers, while providing support for the modification of nitrogen-policies on European and global level.

Spotlight on Young Researchers: Ramona Pelich

Ramona Pelich uses data from satellites in space to improve maritime surveillance and flood hazard monitoring. Splitting her time between the Luxembourg Institute of Science and Technology (LIST) and the company LuxSpace as part of her AFR-PPP Postdoc, the Romanian national’s work has already found direct application when flood maps she co-developed were used in the aftermath of destructive 2017 hurricanes Harvey and Irma.

Spotlight on Young Researchers: Jose-Luis Sanchez-Lopez

Jose-Luis Sanchez-Lopez works with multirotor aerial robots – drones. Despite being early in his research career, the Spanish national’s research is already taking off, having secured him several awards at international competitions. After completing his PhD in 2017, Jose-Luis set his sights on Luxembourg, where he works as a Postdoc at the SnT at the University of Luxembourg, with the goal of giving drones enough AI that they can safely operate autonomously in a range of environments.

Overcoming antiquated ideas about history

To many, the Middle Ages are synonymous with the term the ‘Dark Ages’ – a time of decline. The term was coined hundreds of years ago by the era referring to itself as the ‘Renaissance’ – a rebirth of norms and standards. There is in fact much more to the complexity of the Middle Ages and historians are working on overcoming these antiquated ideas. For this research, Dr Christa Birkel won a 2021 FNR Award in the category ‘Outstanding PhD Thesis’.

Spotlight on Young Researchers: Damien Brevers

Postdoc Damien Brevers has a passion for studying self-control abilities in humans. Having spent time in Belgium and the US building expertise in areas including clinical psychology, sport psychology and brain imaging, the Belgian national has just joined the University of Luxembourg and embarked on a project looking at gambling addiction in the age of online betting.

Spotlight on Young Researchers: Understanding how language manifests in the brain

At KU Leuven, Luxembourg national Jill Kries is part of a research team driven by understanding how cognition and brain structure develop over time in language-related disorders and how this knowledge can be applied in a clinical or educational setting. We take a closer look at the work of the young team.

Spotlight on Young Researchers: Christof Ferreira Torres

Can we truly trust current blockchain technology to securely automate important processes in the financial sector? Christof Ferreira Torres wants to answer this question. In the framework of his Industrial Fellowship PhD with the University of Luxembourg and the bank Spuerkeess (BCEE), the Portuguese national works on the security of smart contracts and the detection of fraudulent transactions – because gaps in security can quickly mean high costs for thousands of people.

Spotlight on Young Researchers: Noémie Catherine Engel

Noémie Catherine Engel has just begun her researcher journey – and she has found her niche already: As part of her AFR PhD at the University of Bath, the Luxembourg national investigates the evolution of sex role traits in a small shorebird species in Cape Verde.

Spotlight on Young Researchers: Collecting individual and personal stories of the war generation in Luxembourg

Over 10,000 Luxembourgish women and men wore German uniforms during WWII in armed forces and civil organisations – many were drafted by the Nazi German authorities – and behind each name is a story waiting to be told. A team of researchers has been working with families in Luxembourg to piece together the personal stories of the war generation in Luxembourg.

Spotlight on Young Researchers: Lucas Oesch

Luxembourg is one of many countries experiencing the arrival of asylum seekers and refugees that have been displaced for reasons such as conflicts or instability in their own country. Managing a research team for the first time, CORE Junior PI Lucas Oesch leads the project ‘REFUGOV’ at the University of Luxembourg, which looks at the accommodation of asylum seekers and refugees in cities and camps.

Spotlight on Young Researchers: A gas sensor powered by natural light

Many of the things we furnish our homes and office with emit gases that we are oblivious to inhaling. As eliminating these items from our lives is unrealistic, science wants to understand that which we cannot eliminate, thus more effective sensors are needed. Material scientist Rutuja Bhusari combines materials at nanoscale to create a gas sensor powered by nature.

Spotlight on Young Researchers: Glioblastoma and the challenge of getting cancer drugs to reach the brain

Glioblastoma is the most aggressive form of brain tumours in adults. The incidence is about 4 per 100.000 people and the average survival after diagnosis is about 14 months with current treatments. The tumour’s location represents a major challenge – few drugs make it past the blood brain barrier. Researchers are working on designing a novel kind of drug that could help do just that.

Spotlight on Young Researchers: Anna Scaini

Anna Scaini’s appetite for becoming a researcher was stirred at University, stemming from a desire to ‘save’ the last natural river in Europe, which runs close to her home town and causes dangerous local flooding. The Italian national is taking the first step towards pursuing her goal as she prepares to complete her PhD thesis in Hydrology at the Luxembourg Institute of Science and Technology (LIST).

Spotlight on Young Researchers: Foni Raphaël Lebrun-Ricalens

Quantum computing is one of the hottest topics in physical sciences. As part of his AFR PhD at the University of Sussex, Luxembourg national Foni Raphaël Lebrun-Ricalens works on developing a quantum computer – a technology that has the potential to revolutionise computing. Recently, he was also asked to evaluate the science behind the ‘quantum realm’ in the final ‘Avengers’ film.

Spotlight on Young Researchers: Gil Georges

Gil Georges is driven by the quest for knowledge and strives to have a real impact, beyond publications. The Luxembourg national has just made the jump from early-career researcher to lecturer and group leader at the IET-LAV at ETH Zürich in Switzerland, where the data analyst and modeller gets to use one of Europe’s most powerful super computers when it is time for some serious number crunching.

Spotlight on Young Researchers: Nature’s shapes as mathematical challenges

In nature, we see hyperbolic forms in corals, flatworms, and many other species of reef organisms, such as sponges and kelps. The hyperbolic spaces are also of interest for mathematicians, who are looking to prove the solvability of invariant systems of differential equations in unusual spaces such as these.

Spotlight on Young Researchers: Membranes for clean water

As the global population sharply increases, so does the demand for clean water. At the same time, freshwater is gradually being depleted. Combine these two factors, and we have the potential for widespread water shortages – it is estimated that half of European basins will be experiencing water stress by 2030, and that 6 billion people will suffer from clean water scarcity by 2050. Researchers are working on cost-effective practices to address this impending crisis.

Spotlight on Young Researchers: The role a gene plays in neurodegeneration and cancer

Neurogenerative diseases and cancer affect millions of people worldwide, especially people over 60. While advances in diagnosis and treatment have been made, there are still many open questions on the path to better treatment and earlier diagnosis. Translational neuroscientist Pauline Mencke studies a gene that is involved both in Parkinson’s disease and the brain cancer Glioblastoma multiforme.

Spotlight on Young Researchers: Sebastian Scheer

Senior Postdoc Sebastian Scheer’s thirst for understanding how biological systems work led him to dive into the world of immunology research. After moving from Germany to Canada, the Luxembourg national got the chance to set up his group leader’s new lab in Australia, where his research revolves around the T cell, a key player in the shaping of immune responses.

Spotlight on Young Researchers: Mohammad Zare

Floods across the world have resulted in tremendous economic damage and loss of lives: better tools to predict flood rise and recession are needed. The biggest question facing researchers like Mohammad Zare is how to accurately simulate and predict this complex phenomenon. As part of an Industrial Fellowship between the University of Luxembourg and company RSS-Hydro, the Postdoc Works on improving the simulation and prediction of flash floods, with the goal to develop a decision-making model for flood protection in Luxembourg.

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