Spotlight on Young Researchers: Charles de Bourcy

 

Charles de Bourcy decided to become a researcher on human health when he realised the human body is not invincible. After completing his undergraduate studies at University of Oxford, the Luxembourg national secured one of the most prestigious scholarships in the world and embarked on a PhD at Stanford University. Now in the final year of this PhD in Applied Physics, Charles is taking his first steps towards his goal of building technologies to help ease the burden of global disease.

Charles de Bourcy’s job in his PhD has been to try to find aspects of the human immune system that can be engineered to prevent or treat life-threatening diseases.

“My PhD projects focus on how immune cells can go wrong in old age, how they can be affected by immunotherapy for systemic sclerosis, and how we might prevent cancer-fighting cells from falling into a dysfunctional ‘exhausted’ state”, Charles explains.

Charles adds that this involves using the latest advances in genomics technology, combined with high-performance computing and quantitative analytics.

“Early on, a lot of time might be spent preparing blood samples for DNA sequencing, which means pipetting reagents. Later on, I spend most of my time coding to carry out computational analysis. In the afternoons, I often meet with the collaborators to discuss progress or learn about advances from other research groups. In the final phase of a project, I spend my days writing and preparing figures for publication.”

“I was drawn to the profound impact a researcher can have”

Charles explains his passion for research was triggered by the realisation that the human body is not invincible – that there are infectious diseases, cancers, autoimmune diseases and more that still have extremely limited treatment options.

“This feeling of helplessness pushed me to work on problems in human health. I was drawn to the profound impact the work of a researcher can have: a single discovery can change the paradigm for how an entire class of diseases are handled.

“For example, synthetic biology has enabled engineered immune cells against tumors, which have the potential to improve outcomes for a whole range of different cancers.

“Part of the fun is that such breakthroughs often happen in indirect ways — there’s this saying that the light bulb wasn’t invented by someone trying to make a better candle.”

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable”

In terms of what Charles wants to achieve as a scientist, he explains that he wants to help reduce the global disease burden, by building technologies that enable diseases to be treated – or prevented – in the best possible way:

“My first step in this endeavor has been to develop tools that allow previously impenetrable aspects of immunology to be measured quantitatively.

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable – advances in genomics, image processing and machine learning could be used to great effect in medicine, particularly if leveraged at a large scale.

“For example, surveys of immune repertoires and viral evolution across the globe could lead to more efficacious vaccine development and allow epidemics to be managed better, before they develop into catastrophic pandemics.”

Charles left Luxembourg for his undergraduate studies at the University of Oxford in the UK, before moving to Stanford University in California for his PhD. Even though Charles has been away for some years, he has been keeping an eye on the research landscape in Luxembourg for his future scientific plans:

“I have been following the development of Luxembourg’s research infrastructure with excitement. The country is pouring a lot of resources into expanding its research activity, making it a very attractive place to launch ambitious projects.”

Charles is now finishing up his PhD in Applied Physics at Stanford University. Charles’ PhD was funded by the International Fulbright Science & Technology Award and by the Melvin and Joan Lane Stanford Graduate Fellowship.

Meeting Nobel Prize winners

Charles was one of 400 early-career scientists selected to attend 2015 Lindau Nobel Laureate Meeting, with his attendance sponsored by the FNR – read an interview with Charles about the experience.

Charles at the 2015 Lindau Nobel Laureate Meeting, here with Françoise Barré-Sinoussi, 2008 recipient of the Nobel Prize in Physiology or Medicine for the discovery of HIV.
Charles de Bourcy

About Spotlight on Young Researchers

Spotlight on Young Researchers is an FNR initiative to highlight early career researchers across the world who have a connection to Luxembourg. This article is the 17th in a series of around 25 articles, which will be published on a weekly basis. You can see more articles below as and when they are published.

Spotlight on Young Researchers: Amy Parrish

During her Master’s studies, Amy Parrish found her passion for research with a clinical aspect. Having come from London to Luxembourg to pursue her AFR PhD at the Luxembourg Institute of Health (LIH) in the research group of Mahesh Desai, the American national studies the bacteria that inhabit our gut, to shed light on the development of diseases such as Inflammatory Bowel Disease (IBD).

Spotlight on Young Researchers: Taking language barriers out of the equation

Luxembourg nationals Max Greisen and Véronique Cornu have many things in common: They are both educated in the field of psychology, they are both PhD researchers at the University of Luxembourg – and they both work with language-free approaches to early mathematical development of multilingual children. Max develops and implements animations that help assess early numerical competencies, while Véronique develops training methods to help overcome language barriers in early math education.

Spotlight on Young Researchers: The challenge of getting autonomous systems to work together seamlessly

An increasing number of systems are now controlled by artificial intelligence (AI): Autonomous vehicles – such as drones or satellites – can be deployed in difficult to access places and used to gather information in real-time. Autonomous systems can also be used simultaneously and cooperate to reach better performances compared to using only one device – but not without challenges: it is no easy task to programme these entities to behave collectively as we want them to. We speak to computer scientist and researcher Florian Felten about his research in this area and the associated challenges.

Spotlight on Young Researchers: Assessing the sustainability of Luxembourgish agriculture

Deforestation and soil degradation is one of many consequences of climate change. Food production systems alone are responsible for around a quarter of annual emissions. Researchers in Luxembourg are working with local actors to create models to help assess the sustainability of Luxembourgish farms.

Spotlight on Young Researchers: Anna Schleimer

In high school, Anna Schleimer thought everything there was to know in science was already known. When she discovered how many unanswered questions there still are, curiosity drove her to become a researcher. The Luxembourg national is now in the 1st year of her AFR PhD, in what is not your most common topic: As a marine biologist, Anna studies fin whales as part of her joint PhD at University of Groningen and University of St Andrews.

Spotlight on Young Researchers: Alex Gansen

Alex Gansen first dabbled in research during his Masters studies in physics at the University of Fribourg (Switzerland), and then decided he wanted to take on the challenge of a PhD, so the Luxembourg national returned to his home country. Alex has just submitted his thesis at the end of the 4th year of his AFR PhD in computational electromagnetics at the Luxembourg Institute of Science and Technology (LIST) in collaboration with the College of Engineering in Swansea. He sees the close links between local industry and research in Luxembourg as a great advantage for the future of research in the Grand Duchy.

Spotlight on Young Researchers: Laurie Maldonado

Laurie Maldonado’s research focuses on single-parent families. After suddenly becoming a single parent herself, she experienced first-hand how quickly single-parent families can fall into poverty in the United States, not knowing if she could continue her research. Then Laurie secured an AFR PhD grant, conducting her research at the LIS Cross-National Data Center in Luxembourg and at UCLA. A few years and a successful PhD defence later, we talked with Laurie about her journey and her close-to-home research.

Spotlight on Young Researchers: Konstantinos Papadopoulos

During his computer science studies, Konstantinos Papadopoulos realised how many unexplored areas there are in the field and his desire for becoming a researcher was born. Now in the 2nd year of his PhD at the SnT at the University of Luxembourg, the Greek national works on developing innovative new approaches to security surveillance.

Spotlight on Young Researchers: Gil Georges

Gil Georges is driven by the quest for knowledge and strives to have a real impact, beyond publications. The Luxembourg national has just made the jump from early-career researcher to lecturer and group leader at the IET-LAV at ETH Zürich in Switzerland, where the data analyst and modeller gets to use one of Europe’s most powerful super computers when it is time for some serious number crunching.

Spotlight on Young Researchers: Gilles Tossing

Gilles Tossing’s fascination for the human brain – and why it sometimes fails – led him to the path of research. Now in the second year of his AFR PhD at Université de Montréal in Canada, the Luxembourg national investigates neurodegenerative diseases, with the aim of improving treatments for those affected.

Spotlight on Young Researchers: Paul Hauseux

Paul Hauseux was always interested in science, but only recently settled on the researcher path. Before that, his career ambitions stretched from working in sports or music to teaching science. Some years and a PhD later, the French national has come to Luxembourg for his computational engineering Postdoc in the team of ERC grantee Stéphane Bordas at the University of Luxembourg.

Spotlight on Young Researchers: Silvia Girardi

Silvia Girardi is a sociologist with an interest in studying policies that aim to contrast poverty. As part of her joint PhD at Luxembourg Institute of Socio-Economic Research (LISER) and KU Leuven, the Italian national looks at the social policies that support low-income households in Luxembourg, taking the perspectives of the citizens on the receiving end, and the social workers involved in implementation.

Spotlight on Young Researchers: Ernesto Gargiulo

Ernesto Gargiulo has always had a curious and inquisitive disposition, which as a child saw him spending hours outdoors, in a quest to discover. At University, Ernesto’s attention turned to oncology. Set on applying and strengthening his knowledge, the Italian national embarked on a PhD at the Luxembourg Institute of Health (LIH), where he works on characterising exosomes, small extracellular vesicles, linked to cancer development, progression and chemo-resistance.

Spotlight on Young Researchers: Anna Monzel

Anna Monzel cites her thirst for new knowledge and discoveries as a key contributor in her choosing to follow the path of science. Drawn to Luxembourg because of its interdisciplinary approach, the German national developed a 3D model of the human midbrain for her PhD at the LCSB at the University of Luxembourg – which earned her a Lush Young Researcher Prize.

Spotlight on Young Researchers: Isabel Z. Martínez

Isabel Z. Martínez has been interested in how policies are put in place and how they affect people’s lives for as long as she can remember. After completing her Masters in Economics, she realised that academia was the ideal way to quench her thirst for analysing large data sets and finding answers to questions addressing people’s well-being and policy decisions. The Swiss-Spanish national has been studying income and wealth inequality in Switzerland for years and has now come to Luxembourg as a Postdoc at LISER to expand her research to the Grand Duchy. We spoke to Isabel about life as a research economist, and how it has already enabled her to travel across the globe, as well as work with some of the foremost researchers in her field.

Spotlight on Young Researchers: Jose-Luis Sanchez-Lopez

Jose-Luis Sanchez-Lopez works with multirotor aerial robots – drones. Despite being early in his research career, the Spanish national’s research is already taking off, having secured him several awards at international competitions. After completing his PhD in 2017, Jose-Luis set his sights on Luxembourg, where he works as a Postdoc at the SnT at the University of Luxembourg, with the goal of giving drones enough AI that they can safely operate autonomously in a range of environments.

Spotlight on Young Researchers: AI for ethical and legal debates

Looking at popular culture, big tech and ongoing societal debates – technological progress in Artificial Intelligence (AI) affects us all. Researchers from numerous scientific fields are working on the best way to bring AI forward, including the study of systems able to autonomously reason over arguments – calculators for philosophical, ethical or legal debates.

Spotlight on Young Researchers – revisited 5 years later: A post-PhD life in finance

When Eric Finn Schaanning was featured in Spotlight on Young Researchers in 2017, he had just defended his AFR PhD on fire sales and systemic risk in financial networks at Imperial College London. In 2017, Eric attended the Lindau Nobel Laureate Meeting and in 2018, won an FNR Award for his PhD thesis. 5 years after his PhD, we catch up with Eric, who has been working on cyber risks, financial and regulatory stress tests as well operational risk management – a career spanning Norway, Frankfurt and Zürich – and reflect on the value his PhD has added.

Spotlight on Young Researchers: László Sándor

For László Sándor research is the ultimate war against ‘fake news’. After completing his PhD in Economics at Harvard, the Hungarian-American national chose a Postdoc position at the Luxembourg School of Finance at the University of Luxembourg, where his work includes big data projects, field experiments in household finance and applied microeconomics.

Spotlight on Young Researchers: Lucas Oesch

Luxembourg is one of many countries experiencing the arrival of asylum seekers and refugees that have been displaced for reasons such as conflicts or instability in their own country. Managing a research team for the first time, CORE Junior PI Lucas Oesch leads the project ‘REFUGOV’ at the University of Luxembourg, which looks at the accommodation of asylum seekers and refugees in cities and camps.

Spotlight on Young Researchers: Steve Dias Da Cruz

While machine learning and deep learning have come a long way, they are not yet at a stage where autonomous vehicles can handle unexpected situations. As part of a public research-industry collaboration, early career researcher Steve Dias Da Cruz investigates possibilities to reduce the amount of data needed to train reliable deep learning models for safety critical applications in the automotive industry.

Spotlight on Young Researchers: An algorithm to allocate satellite resources

When the first satellite was launched in the 1950s, earth orbit was a lonely place. Since then, more than 11,000 satellites have been launched into space and over 3,000 are still in operation. Estimates suggest an exponential increase in satellites in the next years, creating a challenge for the effective allocation of the needed bandwidth and power. Researchers are developing algorithms to more effectively allocate the resources where and when they are needed.

Spotlight on Young Researchers: Michel Summer

For his AFR PhD at Trinity College Dublin, historian Michel Summer is re-assessing the political activity of medieval Anglo-Saxon missionary Willibrord, who in addition to being a landowner, scholar and ambassador, founded a monastery in Luxembourg. We spoke to the Luxembourg national about how history promotes critical thinking, and why he believes historians are needed more than ever.

Spotlight on Young Researchers: Foni Raphaël Lebrun-Ricalens

Quantum computing is one of the hottest topics in physical sciences. As part of his AFR PhD at the University of Sussex, Luxembourg national Foni Raphaël Lebrun-Ricalens works on developing a quantum computer – a technology that has the potential to revolutionise computing. Recently, he was also asked to evaluate the science behind the ‘quantum realm’ in the final ‘Avengers’ film.

Spotlight on Young Researchers: Remko Nijzink

Climate change affects vegetation and water resources. In order to understand these changes, scientists use models – an abstract, mathematical representation of an ecological system. The challenge: Making accurate predictions under change, without ‘tuning’ models with data. We speak to Dutch national Remko Nijzink, Postdoc in the group of FNR ATTRACT Fellow Dr. Stan Schymanski at the Luxembourg Institute of Science and Technology (LIST), about his modelling work and the importance of an open science approach.

This site uses cookies. By continuing to use this site, you agree to the use of cookies for analytics purposes. Find out more in our Privacy Statement