Spotlight on Young Researchers: Charles de Bourcy

 

Charles de Bourcy decided to become a researcher on human health when he realised the human body is not invincible. After completing his undergraduate studies at University of Oxford, the Luxembourg national secured one of the most prestigious scholarships in the world and embarked on a PhD at Stanford University. Now in the final year of this PhD in Applied Physics, Charles is taking his first steps towards his goal of building technologies to help ease the burden of global disease.

Charles de Bourcy’s job in his PhD has been to try to find aspects of the human immune system that can be engineered to prevent or treat life-threatening diseases.

“My PhD projects focus on how immune cells can go wrong in old age, how they can be affected by immunotherapy for systemic sclerosis, and how we might prevent cancer-fighting cells from falling into a dysfunctional ‘exhausted’ state”, Charles explains.

Charles adds that this involves using the latest advances in genomics technology, combined with high-performance computing and quantitative analytics.

“Early on, a lot of time might be spent preparing blood samples for DNA sequencing, which means pipetting reagents. Later on, I spend most of my time coding to carry out computational analysis. In the afternoons, I often meet with the collaborators to discuss progress or learn about advances from other research groups. In the final phase of a project, I spend my days writing and preparing figures for publication.”

“I was drawn to the profound impact a researcher can have”

Charles explains his passion for research was triggered by the realisation that the human body is not invincible – that there are infectious diseases, cancers, autoimmune diseases and more that still have extremely limited treatment options.

“This feeling of helplessness pushed me to work on problems in human health. I was drawn to the profound impact the work of a researcher can have: a single discovery can change the paradigm for how an entire class of diseases are handled.

“For example, synthetic biology has enabled engineered immune cells against tumors, which have the potential to improve outcomes for a whole range of different cancers.

“Part of the fun is that such breakthroughs often happen in indirect ways — there’s this saying that the light bulb wasn’t invented by someone trying to make a better candle.”

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable”

In terms of what Charles wants to achieve as a scientist, he explains that he wants to help reduce the global disease burden, by building technologies that enable diseases to be treated – or prevented – in the best possible way:

“My first step in this endeavor has been to develop tools that allow previously impenetrable aspects of immunology to be measured quantitatively.

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable – advances in genomics, image processing and machine learning could be used to great effect in medicine, particularly if leveraged at a large scale.

“For example, surveys of immune repertoires and viral evolution across the globe could lead to more efficacious vaccine development and allow epidemics to be managed better, before they develop into catastrophic pandemics.”

Charles left Luxembourg for his undergraduate studies at the University of Oxford in the UK, before moving to Stanford University in California for his PhD. Even though Charles has been away for some years, he has been keeping an eye on the research landscape in Luxembourg for his future scientific plans:

“I have been following the development of Luxembourg’s research infrastructure with excitement. The country is pouring a lot of resources into expanding its research activity, making it a very attractive place to launch ambitious projects.”

Charles is now finishing up his PhD in Applied Physics at Stanford University. Charles’ PhD was funded by the International Fulbright Science & Technology Award and by the Melvin and Joan Lane Stanford Graduate Fellowship.

Meeting Nobel Prize winners

Charles was one of 400 early-career scientists selected to attend 2015 Lindau Nobel Laureate Meeting, with his attendance sponsored by the FNR – read an interview with Charles about the experience.

Charles at the 2015 Lindau Nobel Laureate Meeting, here with Françoise Barré-Sinoussi, 2008 recipient of the Nobel Prize in Physiology or Medicine for the discovery of HIV.
Charles de Bourcy

About Spotlight on Young Researchers

Spotlight on Young Researchers is an FNR initiative to highlight early career researchers across the world who have a connection to Luxembourg. This article is the 17th in a series of around 25 articles, which will be published on a weekly basis. You can see more articles below as and when they are published.

Spotlight on Young Researchers: Membranes for clean water

As the global population sharply increases, so does the demand for clean water. At the same time, freshwater is gradually being depleted. Combine these two factors, and we have the potential for widespread water shortages – it is estimated that half of European basins will be experiencing water stress by 2030, and that 6 billion people will suffer from clean water scarcity by 2050. Researchers are working on cost-effective practices to address this impending crisis.

Spotlight on Young Researchers: Turning up the heat on solar absorbers

Using solar absorbers for collection and storage of heat from the sun is an environmentally friendly way to generate heat, yet only 16% of heating is generated from renewable energy. Material scientists are looking for ways to boost this number by making the solar absorber coatings more efficient.

Spotlight on Young Researchers: The historical relationship between the European Community and the Soviet Union

As war rages in Ukraine, the topic PhD candidate Claude Ewert has been researching for the past three years is perhaps more relevant now than ever: the relationship between the European Community and the Soviet Union. The historian is gathering valuable information on the EC’s early foreign policy and the obstacles that had to be overcome to try to make the Community speak with one voice.

Spotlight on Young Researchers: Increasing the diversity of plant species used for vegetable oil

Vegetable oil – mainly palm oil – is heavily relied upon in the production of food, cosmetics, and biofuel. The increase in droughts also affects the standard cultivation of palm oil – alternatives are needed. Agricultural scientists are investigating the potential of a new alternative drought-resistant source for the most widely-used kind of vegetable oil.

Spotlight on Young Researchers: Steve Dias Da Cruz

While machine learning and deep learning have come a long way, they are not yet at a stage where autonomous vehicles can handle unexpected situations. As part of a public research-industry collaboration, early career researcher Steve Dias Da Cruz investigates possibilities to reduce the amount of data needed to train reliable deep learning models for safety critical applications in the automotive industry.

Spotlight on Young Researchers: Understanding the impact climate change has on crop-threatening insects

A type of insect known as whitefly spreads plant viruses and has devastating effects on the vegetables that we depend on and thanks to climate change their negative impact on agriculture is set to increase in the future. Current methods to protect crops depend on delicate relationships between whiteflies and their natural enemies, our crops, and microbial communities, a delicate balance threatened by climate change. Researchers are working with a ‘climate in the lab’ to get a better understanding of what could happen, with the ultimate goal to generate solutions to protect food security.

Spotlight on Young Researchers: Foni Raphaël Lebrun-Ricalens

Quantum computing is one of the hottest topics in physical sciences. As part of his AFR PhD at the University of Sussex, Luxembourg national Foni Raphaël Lebrun-Ricalens works on developing a quantum computer – a technology that has the potential to revolutionise computing. Recently, he was also asked to evaluate the science behind the ‘quantum realm’ in the final ‘Avengers’ film.

Spotlight on Young Researchers: Adham Ayman Al-Sayyad

Adham Ayman Al-Sayyad is a PhD researcher working on multidisciplinary cross-border project. In our article, we explore the Egyptian national’s research around the topic of laser beam joining; why his next step post-PhD would be to spend some time working in industry to understand his research topic from new angles; and his passion for bridging cultures to bring people together.

Spotlight on Young Researchers: AI for ethical and legal debates

Looking at popular culture, big tech and ongoing societal debates – technological progress in Artificial Intelligence (AI) affects us all. Researchers from numerous scientific fields are working on the best way to bring AI forward, including the study of systems able to autonomously reason over arguments – calculators for philosophical, ethical or legal debates.

Spotlight on Young Researchers: Glioblastoma and the challenge of getting cancer drugs to reach the brain

Glioblastoma is the most aggressive form of brain tumours in adults. The incidence is about 4 per 100.000 people and the average survival after diagnosis is about 14 months with current treatments. The tumour’s location represents a major challenge – few drugs make it past the blood brain barrier. Researchers are working on designing a novel kind of drug that could help do just that.

Spotlight on Young Researchers: Harnessing the potential of the Internet of Things and satellites to make smart agriculture a reality

Lack of access to fast and reliable Internet in rural and remote areas is a [multi-step] challenge that must be addressed to pave the way for smart agriculture and precision farming, a vital step toward ensuring food security in a changing climate. In the quest for smart agriculture, researchers are working on solutions for connecting Internet of Things (IoT) with satellite communication (SATCOM) systems.

Spotlight on Young Researchers: Empowering critical digital humanities practice

Digitisation has had a significant impact on humanities research: not only has it changed how many scholars conduct their research, it has also led to completely new fields of research, such as digital humanities, a highly interdisciplinary science. Linguist Lorella Viola is interested in how software can enable critical digital humanities practice.

Spotlight on Young Researchers: Michel Summer

For his AFR PhD at Trinity College Dublin, historian Michel Summer is re-assessing the political activity of medieval Anglo-Saxon missionary Willibrord, who in addition to being a landowner, scholar and ambassador, founded a monastery in Luxembourg. We spoke to the Luxembourg national about how history promotes critical thinking, and why he believes historians are needed more than ever.

Spotlight on Young Researchers: Ernesto Gargiulo

Ernesto Gargiulo has always had a curious and inquisitive disposition, which as a child saw him spending hours outdoors, in a quest to discover. At University, Ernesto’s attention turned to oncology. Set on applying and strengthening his knowledge, the Italian national embarked on a PhD at the Luxembourg Institute of Health (LIH), where he works on characterising exosomes, small extracellular vesicles, linked to cancer development, progression and chemo-resistance.

Spotlight on Young Researchers: Martin Řehoř

In industry, computer simulations and optimizations are established approaches to inform and improve engineering designs. As part of his Industrial Fellowship, Postdoc Martin Řehoř works on numerical solvers that could help solve design problems that involve the processing of fluids.

Spotlight on Young Researchers: Gilles Tossing

Gilles Tossing’s fascination for the human brain – and why it sometimes fails – led him to the path of research. Now in the second year of his AFR PhD at Université de Montréal in Canada, the Luxembourg national investigates neurodegenerative diseases, with the aim of improving treatments for those affected.

Spotlight on Young Researchers: Maria Pires Pacheco

Maria Pires Pacheco is a problem solver with a fondness for coding, who was always drawn to the scientist in a group of heroes, rather than the classic hero. During her AFR PhD, the Luxembourg national worked on building tools that help simulate the metabolism of a cell, tools she applied to cancer research during her postdoc.

Spotlight on Young Researchers: Toward a risk assessment system for natural and biological systems

Is it possible to use mathematical indicators to alert about natural disasters and help in the early detection of disease and health issues? Over the past 15 years, scientists have been working on bridging mathematical theory and empirical evidence to do just that. To move the science forward, a key challenge is the underlying mathematical problem, as well as determining how the indicators should be applied.

Spotlight on Young Researchers: Anjali Sharma

In school, we are taught three states of matter: solid, liquid and gas. The focus of University of Luxembourg PhD candidate Anjali Sharma’s research lies between solid and liquid: liquid crystal. She studies them in unusual shapes that are no larger than the width of a human hair, yet they are considered as large by the scientists of the field. As part of her research, the Indian national got an opportunity for a rare experiment: Taking her research into a zero gravity environment.

Spotlight on Young Researchers: Gil Georges

Gil Georges is driven by the quest for knowledge and strives to have a real impact, beyond publications. The Luxembourg national has just made the jump from early-career researcher to lecturer and group leader at the IET-LAV at ETH Zürich in Switzerland, where the data analyst and modeller gets to use one of Europe’s most powerful super computers when it is time for some serious number crunching.

Spotlight on Young Researchers: Xianqing Mao

Xianqing Mao comes from a family of professors and doctors and thus has always had a natural interest in science. The Chinese national completed a medical degree, but felt she still had unanswered questions, so she decided to go abroad and took a leap into biomedical research. After stays in France, the UK, the United States and Belgium, Xianqing is now transitioning from junior to senior researcher at the Luxembourg Institute of Health, where she has already been involved in several projects investigating cancer progression.

Spotlight on Young Researchers – revisited 5 years later: A post-PhD life in finance

When Eric Finn Schaanning was featured in Spotlight on Young Researchers in 2017, he had just defended his AFR PhD on fire sales and systemic risk in financial networks at Imperial College London. In 2017, Eric attended the Lindau Nobel Laureate Meeting and in 2018, won an FNR Award for his PhD thesis. 5 years after his PhD, we catch up with Eric, who has been working on cyber risks, financial and regulatory stress tests as well operational risk management – a career spanning Norway, Frankfurt and Zürich – and reflect on the value his PhD has added.

Spotlight on Young Researchers: Silvia Girardi

Silvia Girardi is a sociologist with an interest in studying policies that aim to contrast poverty. As part of her joint PhD at Luxembourg Institute of Socio-Economic Research (LISER) and KU Leuven, the Italian national looks at the social policies that support low-income households in Luxembourg, taking the perspectives of the citizens on the receiving end, and the social workers involved in implementation.

Spotlight on Young Researchers: Towards predicting ageing-related diseases

A rapid increase in both life expectancy and global population size has led to a rise in the prevalence of chronic ageing-associated diseases. Brain and heart age-associated diseases including hypertension, stroke, heart failure, Alzheimer’s and Parkinson’s diseases are leading causes of mortality and disability worldwide. Researchers are working on much-needed ways to predict these diseases.

Spotlight on Young Researchers: Identifying environmental pollutants

Nobody is untouched by environmental chemical pollution, but most are unaware of how they are exposed, what to, and the possible health consequences. With over 350,000 registered chemicals in use, an important first step towards assessing their environmental impacts is to make chemical information more machine-readable and open. Environmental Cheminformatics is on the case.

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