Spotlight on Young Researchers: Charles de Bourcy

 

Charles de Bourcy decided to become a researcher on human health when he realised the human body is not invincible. After completing his undergraduate studies at University of Oxford, the Luxembourg national secured one of the most prestigious scholarships in the world and embarked on a PhD at Stanford University. Now in the final year of this PhD in Applied Physics, Charles is taking his first steps towards his goal of building technologies to help ease the burden of global disease.

Charles de Bourcy’s job in his PhD has been to try to find aspects of the human immune system that can be engineered to prevent or treat life-threatening diseases.

“My PhD projects focus on how immune cells can go wrong in old age, how they can be affected by immunotherapy for systemic sclerosis, and how we might prevent cancer-fighting cells from falling into a dysfunctional ‘exhausted’ state”, Charles explains.

Charles adds that this involves using the latest advances in genomics technology, combined with high-performance computing and quantitative analytics.

“Early on, a lot of time might be spent preparing blood samples for DNA sequencing, which means pipetting reagents. Later on, I spend most of my time coding to carry out computational analysis. In the afternoons, I often meet with the collaborators to discuss progress or learn about advances from other research groups. In the final phase of a project, I spend my days writing and preparing figures for publication.”

“I was drawn to the profound impact a researcher can have”

Charles explains his passion for research was triggered by the realisation that the human body is not invincible – that there are infectious diseases, cancers, autoimmune diseases and more that still have extremely limited treatment options.

“This feeling of helplessness pushed me to work on problems in human health. I was drawn to the profound impact the work of a researcher can have: a single discovery can change the paradigm for how an entire class of diseases are handled.

“For example, synthetic biology has enabled engineered immune cells against tumors, which have the potential to improve outcomes for a whole range of different cancers.

“Part of the fun is that such breakthroughs often happen in indirect ways — there’s this saying that the light bulb wasn’t invented by someone trying to make a better candle.”

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable”

In terms of what Charles wants to achieve as a scientist, he explains that he wants to help reduce the global disease burden, by building technologies that enable diseases to be treated – or prevented – in the best possible way:

“My first step in this endeavor has been to develop tools that allow previously impenetrable aspects of immunology to be measured quantitatively.

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable – advances in genomics, image processing and machine learning could be used to great effect in medicine, particularly if leveraged at a large scale.

“For example, surveys of immune repertoires and viral evolution across the globe could lead to more efficacious vaccine development and allow epidemics to be managed better, before they develop into catastrophic pandemics.”

Charles left Luxembourg for his undergraduate studies at the University of Oxford in the UK, before moving to Stanford University in California for his PhD. Even though Charles has been away for some years, he has been keeping an eye on the research landscape in Luxembourg for his future scientific plans:

“I have been following the development of Luxembourg’s research infrastructure with excitement. The country is pouring a lot of resources into expanding its research activity, making it a very attractive place to launch ambitious projects.”

Charles is now finishing up his PhD in Applied Physics at Stanford University. Charles’ PhD was funded by the International Fulbright Science & Technology Award and by the Melvin and Joan Lane Stanford Graduate Fellowship.

Meeting Nobel Prize winners

Charles was one of 400 early-career scientists selected to attend 2015 Lindau Nobel Laureate Meeting, with his attendance sponsored by the FNR – read an interview with Charles about the experience.

Charles at the 2015 Lindau Nobel Laureate Meeting, here with Françoise Barré-Sinoussi, 2008 recipient of the Nobel Prize in Physiology or Medicine for the discovery of HIV.
Charles de Bourcy

About Spotlight on Young Researchers

Spotlight on Young Researchers is an FNR initiative to highlight early career researchers across the world who have a connection to Luxembourg. This article is the 17th in a series of around 25 articles, which will be published on a weekly basis. You can see more articles below as and when they are published.

Spotlight on Young Researchers: Michel Summer

For his AFR PhD at Trinity College Dublin, historian Michel Summer is re-assessing the political activity of medieval Anglo-Saxon missionary Willibrord, who in addition to being a landowner, scholar and ambassador, founded a monastery in Luxembourg. We spoke to the Luxembourg national about how history promotes critical thinking, and why he believes historians are needed more than ever.

Spotlight on Young Researchers: Paulo Carvalho

Having started his professional career 16 years ago, Paulo Carvalho did not plan any major career changes. Then an opportunity came up that would change work life as he knew it and a few years later, the French/Portuguese national is completing his PhD at the Luxembourg Institute of Science and Technology (LIST).

Spotlight on Young Researchers: Assessing the sustainability of Luxembourgish agriculture

Deforestation and soil degradation is one of many consequences of climate change. Food production systems alone are responsible for around a quarter of annual emissions. Researchers in Luxembourg are working with local actors to create models to help assess the sustainability of Luxembourgish farms.

Spotlight on Young Researchers: Yamila Mariel Omar

As part of her Industrial Fellowship – a collaboration between the University of Luxembourg and company Husky – PhD candidate Yamila Mariel Omar helps industry to monetize their proprietary data by means of big data analytics. We speak to the Argentinian national who also became a mother during her PhD.

Spotlight on Young Researchers: A fully automatic flood mapping algorithm

Flooding presents a major hazard in both rural and urban areas. Luxembourg was also affected by the significant floods that devastated parts of Germany in July 2021. With the goal of predicting areas that will flood, scientists are working on various aspects of flood-mapping using satellite data.

Spotlight on Young Researchers: Dominique Santana

After completing her master’s degree, Luxembourg national Dominique Santana decided to spend time in her mother’s birth country Brazil. While there, she became intrigued by Brazil’s communities of Luxembourgish nationals and wanted to investigate further. Now in the first year of her AFR PhD at the C²DH at the University of Luxembourg, Dominique is examining the paths of Luxembourgers who emigrated to Brazil from 1920 – 1965, which has already rekindled old friendships.

Spotlight on Young Researchers: Toward a risk assessment system for natural and biological systems

Is it possible to use mathematical indicators to alert about natural disasters and help in the early detection of disease and health issues? Over the past 15 years, scientists have been working on bridging mathematical theory and empirical evidence to do just that. To move the science forward, a key challenge is the underlying mathematical problem, as well as determining how the indicators should be applied.

Spotlight on Young Researchers: Anna Monzel

Anna Monzel cites her thirst for new knowledge and discoveries as a key contributor in her choosing to follow the path of science. Drawn to Luxembourg because of its interdisciplinary approach, the German national developed a 3D model of the human midbrain for her PhD at the LCSB at the University of Luxembourg – which earned her a Lush Young Researcher Prize.

Spotlight on Young Researchers: Hussein Rappel

Hussein Rappel uses a mathematical learning approach to try to predict and simulate physical phenomena. The Iranian national came to Luxembourg in 2014 to join the team of Prof Stephane Bordas at the University of Luxembourg, where he is now in the 3rd year of his PhD in Computational Science – and sees great potential in Luxembourg as a research destination.

Spotlight on Young Researchers: Cyrille Thinnes

In 2015, Cyrille Thinnes was featured in our campaign ‘Spotlight on Young Researchers’, which highlighted early-career researchers with a connection to Luxembourg. At the time, Cyrille was at the University of Oxford doing a DPhil (PhD) in chemical biology. One year on, we caught up with Cyrille!

Overcoming antiquated ideas about history

To many, the Middle Ages are synonymous with the term the ‘Dark Ages’ – a time of decline. The term was coined hundreds of years ago by the era referring to itself as the ‘Renaissance’ – a rebirth of norms and standards. There is in fact much more to the complexity of the Middle Ages and historians are working on overcoming these antiquated ideas. For this research, Dr Christa Birkel won a 2021 FNR Award in the category ‘Outstanding PhD Thesis’.

Spotlight on Young Researchers: Dementia in neurodegeneration – defining the role of microglia, the brain’s immune cells

An estimated 55 million people in the world suffer from dementia, with the number estimated to increase to 78 million by 2030. In Luxembourg, more than 10,000 people suffer from dementia, including patients affected by Alzheimer’s disease and Dementia with Lewy Bodies. These incurable diseases have an increasing socio-economic impact along with the burden on patients and caregivers. One of the approaches researchers are taking is studying microglia, immune cells in the brain.

Spotlight on Young Researchers: Maria Pires Pacheco

Maria Pires Pacheco is a problem solver with a fondness for coding, who was always drawn to the scientist in a group of heroes, rather than the classic hero. During her AFR PhD, the Luxembourg national worked on building tools that help simulate the metabolism of a cell, tools she applied to cancer research during her postdoc.

Spotlight on Young Researchers: Thomas Schaubroeck

Thomas Schaubroeck specialises in sustainability assessment of products. We speak to the Belgian national about the research he is undertaking in the framework of an Industrial Fellowship between the Luxembourg Institute of Science and Technology (LIST) and company Tarkett; how working with industry differs from academia; and how he hopes his research can help industry steer toward a more sustainable future.

Spotlight on Young Researchers: Konstantinos Papadopoulos

During his computer science studies, Konstantinos Papadopoulos realised how many unexplored areas there are in the field and his desire for becoming a researcher was born. Now in the 2nd year of his PhD at the SnT at the University of Luxembourg, the Greek national works on developing innovative new approaches to security surveillance.

Spotlight on Young Researchers: Guillaume Nataf

“Would matter be perfect, it would be boring” says Guillaume Nataf, who has an oozing passion for physics and teaching fundamental science. The French national did his PhD in the group of FNR PEARL Chair Jens Kreisel at the Luxembourg Institute of Science and Technology (LIST), in collaboration with the French Atomic Commission (CEA). We spoke to Guillaume, who has just started a Postdoc at the University of Cambridge, about life as a researcher.

Spotlight on Young Researchers: Understanding how language manifests in the brain

At KU Leuven, Luxembourg national Jill Kries is part of a research team driven by understanding how cognition and brain structure develop over time in language-related disorders and how this knowledge can be applied in a clinical or educational setting. We take a closer look at the work of the young team.

Spotlight on Young Researchers: Gilles Tossing

Gilles Tossing’s fascination for the human brain – and why it sometimes fails – led him to the path of research. Now in the second year of his AFR PhD at Université de Montréal in Canada, the Luxembourg national investigates neurodegenerative diseases, with the aim of improving treatments for those affected.

Spotlight on Young Researchers: Anjali Sharma

In school, we are taught three states of matter: solid, liquid and gas. The focus of University of Luxembourg PhD candidate Anjali Sharma’s research lies between solid and liquid: liquid crystal. She studies them in unusual shapes that are no larger than the width of a human hair, yet they are considered as large by the scientists of the field. As part of her research, the Indian national got an opportunity for a rare experiment: Taking her research into a zero gravity environment.

Spotlight on Young Researchers: The historical relationship between the European Community and the Soviet Union

As war rages in Ukraine, the topic PhD candidate Claude Ewert has been researching for the past three years is perhaps more relevant now than ever: the relationship between the European Community and the Soviet Union. The historian is gathering valuable information on the EC’s early foreign policy and the obstacles that had to be overcome to try to make the Community speak with one voice.

Spotlight on Young Researchers: Understanding drug resistance in skin cancer

Melanoma is a rare type of skin cancer, but it is the deadliest type – and incidence is on the rise. Metastatic melanoma has seen a rapid emergence in drug resistance: After a few months, treatment stops working and tumours begin to grow again. Molecular biologists are working to understand why this happens.

Spotlight on Young Researchers: Katharina Baum

When Katharina Baum was a teenager, her mother took her to a presentation about the Human Genome Project. Fascinated, she stood up and asked what she would have to do to be able to study genes. Some years and a degree in mathematics later, the German national and mother of two children now splits her time between Luxembourg and Berlin as part of her two postdocs. In her work at the Luxembourg Institute of Health, Katharina combines computer science, maths and biology to identify faulty regulatory mechanisms in cancerous cells.

Spotlight on Young Researchers: Nanotechnology – a future big player in health

Divya Balakrishnan, Dipti Rani and Serena Rollo are women in science working in a field that could have a major impact on how health is managed: In the group of FNR ATTRACT Fellow César Pascual García at the Luxembourg Institute of Science and Technology (LIST), the team works on developing sensors for biochemical applications focusing on medicine.

Spotlight on Young Researchers: Foni Raphaël Lebrun-Ricalens

Quantum computing is one of the hottest topics in physical sciences. As part of his AFR PhD at the University of Sussex, Luxembourg national Foni Raphaël Lebrun-Ricalens works on developing a quantum computer – a technology that has the potential to revolutionise computing. Recently, he was also asked to evaluate the science behind the ‘quantum realm’ in the final ‘Avengers’ film.

Spotlight on Young Researchers: Jo Hoeser

Ever since he was a child, Jo Hoeser wanted to understand the function of complex systems. He found himself taking apart and trying to fix broken electronic devices. Then fascination for chemistry came into the mix. Fast forward some years and the Luxembourg national completed his AFR PhD in biochemistry at the Albert-Ludwigs University Freiburg – and wants to return to the Grand Duchy to continue his career in research.

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