Spotlight on Young Researchers: Charles de Bourcy

 

Charles de Bourcy decided to become a researcher on human health when he realised the human body is not invincible. After completing his undergraduate studies at University of Oxford, the Luxembourg national secured one of the most prestigious scholarships in the world and embarked on a PhD at Stanford University. Now in the final year of this PhD in Applied Physics, Charles is taking his first steps towards his goal of building technologies to help ease the burden of global disease.

Charles de Bourcy’s job in his PhD has been to try to find aspects of the human immune system that can be engineered to prevent or treat life-threatening diseases.

“My PhD projects focus on how immune cells can go wrong in old age, how they can be affected by immunotherapy for systemic sclerosis, and how we might prevent cancer-fighting cells from falling into a dysfunctional ‘exhausted’ state”, Charles explains.

Charles adds that this involves using the latest advances in genomics technology, combined with high-performance computing and quantitative analytics.

“Early on, a lot of time might be spent preparing blood samples for DNA sequencing, which means pipetting reagents. Later on, I spend most of my time coding to carry out computational analysis. In the afternoons, I often meet with the collaborators to discuss progress or learn about advances from other research groups. In the final phase of a project, I spend my days writing and preparing figures for publication.”

“I was drawn to the profound impact a researcher can have”

Charles explains his passion for research was triggered by the realisation that the human body is not invincible – that there are infectious diseases, cancers, autoimmune diseases and more that still have extremely limited treatment options.

“This feeling of helplessness pushed me to work on problems in human health. I was drawn to the profound impact the work of a researcher can have: a single discovery can change the paradigm for how an entire class of diseases are handled.

“For example, synthetic biology has enabled engineered immune cells against tumors, which have the potential to improve outcomes for a whole range of different cancers.

“Part of the fun is that such breakthroughs often happen in indirect ways — there’s this saying that the light bulb wasn’t invented by someone trying to make a better candle.”

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable”

In terms of what Charles wants to achieve as a scientist, he explains that he wants to help reduce the global disease burden, by building technologies that enable diseases to be treated – or prevented – in the best possible way:

“My first step in this endeavor has been to develop tools that allow previously impenetrable aspects of immunology to be measured quantitatively.

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable – advances in genomics, image processing and machine learning could be used to great effect in medicine, particularly if leveraged at a large scale.

“For example, surveys of immune repertoires and viral evolution across the globe could lead to more efficacious vaccine development and allow epidemics to be managed better, before they develop into catastrophic pandemics.”

Charles left Luxembourg for his undergraduate studies at the University of Oxford in the UK, before moving to Stanford University in California for his PhD. Even though Charles has been away for some years, he has been keeping an eye on the research landscape in Luxembourg for his future scientific plans:

“I have been following the development of Luxembourg’s research infrastructure with excitement. The country is pouring a lot of resources into expanding its research activity, making it a very attractive place to launch ambitious projects.”

Charles is now finishing up his PhD in Applied Physics at Stanford University. Charles’ PhD was funded by the International Fulbright Science & Technology Award and by the Melvin and Joan Lane Stanford Graduate Fellowship.

Meeting Nobel Prize winners

Charles was one of 400 early-career scientists selected to attend 2015 Lindau Nobel Laureate Meeting, with his attendance sponsored by the FNR – read an interview with Charles about the experience.

Charles at the 2015 Lindau Nobel Laureate Meeting, here with Françoise Barré-Sinoussi, 2008 recipient of the Nobel Prize in Physiology or Medicine for the discovery of HIV.
Charles de Bourcy

About Spotlight on Young Researchers

Spotlight on Young Researchers is an FNR initiative to highlight early career researchers across the world who have a connection to Luxembourg. This article is the 17th in a series of around 25 articles, which will be published on a weekly basis. You can see more articles below as and when they are published.

Spotlight on Young Researchers: Measuring the environmental impact of investment funds

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Spotlight on Young Researchers: German Castignani

After doing his Master’s degree and working in the private sector in Argentina, German Castignani decided to do a research internship in France, which piqued his interest for research. After completing his PhD in wireless networking in France, the Italian-Argentinian national came to Luxembourg, where he added an entrepreneurial perspective to his vehicular telematics research, co-founding the SnT’s first spin-off Motion-S.

Spotlight on Young Researchers: How is scientific quality fostered by research collaboration?

In the last decades, how research is conducted has been profoundly changed by ICT, and there has also been a shift from the ‘sole genius’ towards teamwork and especially interdisciplinarity: Today, millions of researchers worldwide collaborate across organisational, disciplinary, and cultural boundaries, extending the possibilities of new scientific discovery. This, and the associated data, has paved the way for the scientific field Science of Science, where one key question is understanding exactly how scientific quality is fostered by research collaboration.

Spotlight on Young Researchers: Maciej Piotr Chrzanowski

Maciej Piotr Chrzanowski never thought he would become a researcher, but a successful attempt at applying for a PhD changed all of that, and the Polish national found himself moving to Luxembourg. Now in the 3rd year of his AFR-PPP PhD, Maciej is embedded both at the University of Luxembourg and in R&D Application Department of steel manufacturing corporation ArcelorMittal, where he works on development of new solutions for structures.

Spotlight on Young Researchers: Kacy Greenhalgh

Kacy Greenhalgh has always had an affectation for medicine and health, and how health can be influenced by dietary habits. During her Master studies, the Luxembourg-American national was introduced to FNR ATTRACT Fellow Paul Wilmes and the ‘gut on a chip’, HuMiX. Fascinated by its potential, and how it could be used to study the relation between diet and health, Kacy’s curiosity led her straight to an AFR PhD at the LCSB at the University of Luxembourg.

Spotlight on Young Researchers: Noémie Catherine Engel

Noémie Catherine Engel has just begun her researcher journey – and she has found her niche already: As part of her AFR PhD at the University of Bath, the Luxembourg national investigates the evolution of sex role traits in a small shorebird species in Cape Verde.

Spotlight on Young Researchers: Increasing the diversity of plant species used for vegetable oil

Vegetable oil – mainly palm oil – is heavily relied upon in the production of food, cosmetics, and biofuel. The increase in droughts also affects the standard cultivation of palm oil – alternatives are needed. Agricultural scientists are investigating the potential of a new alternative drought-resistant source for the most widely-used kind of vegetable oil.

Spotlight on Young Researchers: Hussein Rappel

Hussein Rappel uses a mathematical learning approach to try to predict and simulate physical phenomena. The Iranian national came to Luxembourg in 2014 to join the team of Prof Stephane Bordas at the University of Luxembourg, where he is now in the 3rd year of his PhD in Computational Science – and sees great potential in Luxembourg as a research destination.

Spotlight on Young Researchers: A hazelnut quality forecasting system

Can we predict the likelihood of a hazelnut tree becoming sick? Or what quality defects, and in what percentage, will be present in the final harvest? Science could soon make this possible, thanks to a hazelnut quality forecasting system based on a combination of machine learning and simulation models.

Spotlight on Young Researchers: Foni Raphaël Lebrun-Ricalens

Quantum computing is one of the hottest topics in physical sciences. As part of his AFR PhD at the University of Sussex, Luxembourg national Foni Raphaël Lebrun-Ricalens works on developing a quantum computer – a technology that has the potential to revolutionise computing. Recently, he was also asked to evaluate the science behind the ‘quantum realm’ in the final ‘Avengers’ film.

Spotlight on Young Researchers: Are you what you eat?

Cardiometabolic complications threaten health and reduce life expectancy. In Luxembourg, 1 in 3 people have metabolic syndrome, as a risk factor for cardiometabolic complications such as obesity, high blood sugar and cholesterol, as well as hypertension. Science has shown a link between what we eat and our health – nutritionists are now investigating how dietary strategies could prevent these health complications.

Spotlight on Young Researchers: Assessing the sustainability of Luxembourgish agriculture

Deforestation and soil degradation is one of many consequences of climate change. Food production systems alone are responsible for around a quarter of annual emissions. Researchers in Luxembourg are working with local actors to create models to help assess the sustainability of Luxembourgish farms.

Spotlight on Young Researchers: Michel Summer

For his AFR PhD at Trinity College Dublin, historian Michel Summer is re-assessing the political activity of medieval Anglo-Saxon missionary Willibrord, who in addition to being a landowner, scholar and ambassador, founded a monastery in Luxembourg. We spoke to the Luxembourg national about how history promotes critical thinking, and why he believes historians are needed more than ever.

Spotlight on Young Researchers: Gil Georges

Gil Georges is driven by the quest for knowledge and strives to have a real impact, beyond publications. The Luxembourg national has just made the jump from early-career researcher to lecturer and group leader at the IET-LAV at ETH Zürich in Switzerland, where the data analyst and modeller gets to use one of Europe’s most powerful super computers when it is time for some serious number crunching.

Spotlight on Young Researchers: Hameeda Jagalur Basheer

While solar panels appear on more and more rooftops, researchers are still developing ways to boost their efficiency. As part of her PhD at the Luxembourg Institute of Science and Technology (LIST), Indian national Hameeda Jagalur Basheer is developing alternative materials that can help capture the sunlight better and improve efficiency of solar panels.

Spotlight on Young Researchers: Yamila Mariel Omar

As part of her Industrial Fellowship – a collaboration between the University of Luxembourg and company Husky – PhD candidate Yamila Mariel Omar helps industry to monetize their proprietary data by means of big data analytics. We speak to the Argentinian national who also became a mother during her PhD.

Spotlight on Young Researchers: The role a gene plays in neurodegeneration and cancer

Neurogenerative diseases and cancer affect millions of people worldwide, especially people over 60. While advances in diagnosis and treatment have been made, there are still many open questions on the path to better treatment and earlier diagnosis. Translational neuroscientist Pauline Mencke studies a gene that is involved both in Parkinson’s disease and the brain cancer Glioblastoma multiforme.

Spotlight On Young Researchers: Henderika de Vries

Are creative people better at regulating emotions, and are there cultural differences? This is one of the questions Henderika (Herie) de Vries wants to answer. Having already discovered that cultural differences impact the creative potential of children, the Dutch-Luxembourgish national hopes to understand more aspects of how our cultural circumstances can influence our capacity for creative thinking.

Spotlight on Young Researchers: Antoun Al Absi

Antoun Al Absi has been fascinated by microscopes ever since his parents gave him one as a child. Unsurprisingly, the Syrian-French national cherishes the long hours spent on the microscope as part of his AFR PhD at the Luxembourg Institute of Health (LIH), where he investigates how tumour cells escape the ‘immune surveillance system’, enabling them to spread to other parts of the body.

Spotlight on Young Researchers: Shedding light on female writers in Luxembourg

Always has literature played a major role in the construction of any national identity – yet, Luxembourgish literature is very little known. Researchers are exploring the country’s literary identity, from a Francophone and a gendered perspective, with a particular focus on female writers.

Spotlight on Young Researchers: Laurie Maldonado

Laurie Maldonado’s research focuses on single-parent families. After suddenly becoming a single parent herself, she experienced first-hand how quickly single-parent families can fall into poverty in the United States, not knowing if she could continue her research. Then Laurie secured an AFR PhD grant, conducting her research at the LIS Cross-National Data Center in Luxembourg and at UCLA. A few years and a successful PhD defence later, we talked with Laurie about her journey and her close-to-home research.

Spotlight on Young Researchers: Cyrille Thinnes

In 2015, Cyrille Thinnes was featured in our campaign ‘Spotlight on Young Researchers’, which highlighted early-career researchers with a connection to Luxembourg. At the time, Cyrille was at the University of Oxford doing a DPhil (PhD) in chemical biology. One year on, we caught up with Cyrille!

Spotlight on Young Researchers: Understanding our immune system

Stemming from Italy, Indonesia, Luxembourg, Portugal and Spain, the members of the Experimental & Molecular Immunology Group truly are an international team. In the group of FNR ATTRACT Fellow Prof Dr Dirk Brenner at the Luxembourg Institute of Health (LIH), the team of young researchers investigates different aspects of the immune system with one common goal: Understanding how our immune system is regulated by different mechanisms – and how this knowledge can be used to combat disease.

Spotlight on Young Researchers: Identifying environmental pollutants

Nobody is untouched by environmental chemical pollution, but most are unaware of how they are exposed, what to, and the possible health consequences. With over 350,000 registered chemicals in use, an important first step towards assessing their environmental impacts is to make chemical information more machine-readable and open. Environmental Cheminformatics is on the case.

Spotlight on Young Researchers: Paulo Carvalho

Having started his professional career 16 years ago, Paulo Carvalho did not plan any major career changes. Then an opportunity came up that would change work life as he knew it and a few years later, the French/Portuguese national is completing his PhD at the Luxembourg Institute of Science and Technology (LIST).

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