Spotlight on Young Researchers: Charles de Bourcy

 

Charles de Bourcy decided to become a researcher on human health when he realised the human body is not invincible. After completing his undergraduate studies at University of Oxford, the Luxembourg national secured one of the most prestigious scholarships in the world and embarked on a PhD at Stanford University. Now in the final year of this PhD in Applied Physics, Charles is taking his first steps towards his goal of building technologies to help ease the burden of global disease.

Charles de Bourcy’s job in his PhD has been to try to find aspects of the human immune system that can be engineered to prevent or treat life-threatening diseases.

“My PhD projects focus on how immune cells can go wrong in old age, how they can be affected by immunotherapy for systemic sclerosis, and how we might prevent cancer-fighting cells from falling into a dysfunctional ‘exhausted’ state”, Charles explains.

Charles adds that this involves using the latest advances in genomics technology, combined with high-performance computing and quantitative analytics.

“Early on, a lot of time might be spent preparing blood samples for DNA sequencing, which means pipetting reagents. Later on, I spend most of my time coding to carry out computational analysis. In the afternoons, I often meet with the collaborators to discuss progress or learn about advances from other research groups. In the final phase of a project, I spend my days writing and preparing figures for publication.”

“I was drawn to the profound impact a researcher can have”

Charles explains his passion for research was triggered by the realisation that the human body is not invincible – that there are infectious diseases, cancers, autoimmune diseases and more that still have extremely limited treatment options.

“This feeling of helplessness pushed me to work on problems in human health. I was drawn to the profound impact the work of a researcher can have: a single discovery can change the paradigm for how an entire class of diseases are handled.

“For example, synthetic biology has enabled engineered immune cells against tumors, which have the potential to improve outcomes for a whole range of different cancers.

“Part of the fun is that such breakthroughs often happen in indirect ways — there’s this saying that the light bulb wasn’t invented by someone trying to make a better candle.”

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable”

In terms of what Charles wants to achieve as a scientist, he explains that he wants to help reduce the global disease burden, by building technologies that enable diseases to be treated – or prevented – in the best possible way:

“My first step in this endeavor has been to develop tools that allow previously impenetrable aspects of immunology to be measured quantitatively.

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable – advances in genomics, image processing and machine learning could be used to great effect in medicine, particularly if leveraged at a large scale.

“For example, surveys of immune repertoires and viral evolution across the globe could lead to more efficacious vaccine development and allow epidemics to be managed better, before they develop into catastrophic pandemics.”

Charles left Luxembourg for his undergraduate studies at the University of Oxford in the UK, before moving to Stanford University in California for his PhD. Even though Charles has been away for some years, he has been keeping an eye on the research landscape in Luxembourg for his future scientific plans:

“I have been following the development of Luxembourg’s research infrastructure with excitement. The country is pouring a lot of resources into expanding its research activity, making it a very attractive place to launch ambitious projects.”

Charles is now finishing up his PhD in Applied Physics at Stanford University. Charles’ PhD was funded by the International Fulbright Science & Technology Award and by the Melvin and Joan Lane Stanford Graduate Fellowship.

Meeting Nobel Prize winners

Charles was one of 400 early-career scientists selected to attend 2015 Lindau Nobel Laureate Meeting, with his attendance sponsored by the FNR – read an interview with Charles about the experience.

Charles at the 2015 Lindau Nobel Laureate Meeting, here with Françoise Barré-Sinoussi, 2008 recipient of the Nobel Prize in Physiology or Medicine for the discovery of HIV.
Charles de Bourcy

About Spotlight on Young Researchers

Spotlight on Young Researchers is an FNR initiative to highlight early career researchers across the world who have a connection to Luxembourg. This article is the 17th in a series of around 25 articles, which will be published on a weekly basis. You can see more articles below as and when they are published.

Spotlight on Young Researchers: Measuring the environmental impact of investment funds

Sustainable capital market investments are expected to reach 53 trillion USD – about 1 in every 3 dollars invested – by 2025. Meanwhile, a much lower level of funds are going directly into climate-related projects, leading to an increasing concern of greenwashing in the market. Researchers are developing science-based tools to measure the environmental impact of financial investment decisions.

Spotlight on Young Researchers: Anna Scaini

Anna Scaini’s appetite for becoming a researcher was stirred at University, stemming from a desire to ‘save’ the last natural river in Europe, which runs close to her home town and causes dangerous local flooding. The Italian national is taking the first step towards pursuing her goal as she prepares to complete her PhD thesis in Hydrology at the Luxembourg Institute of Science and Technology (LIST).

Spotlight on Young Researchers: Harnessing the potential of the Internet of Things and satellites to make smart agriculture a reality

Lack of access to fast and reliable Internet in rural and remote areas is a [multi-step] challenge that must be addressed to pave the way for smart agriculture and precision farming, a vital step toward ensuring food security in a changing climate. In the quest for smart agriculture, researchers are working on solutions for connecting Internet of Things (IoT) with satellite communication (SATCOM) systems.

Spotlight on Young Researchers: Assessing the sustainability of Luxembourgish agriculture

Deforestation and soil degradation is one of many consequences of climate change. Food production systems alone are responsible for around a quarter of annual emissions. Researchers in Luxembourg are working with local actors to create models to help assess the sustainability of Luxembourgish farms.

Spotlight on Young Researchers: Anjali Sharma

In school, we are taught three states of matter: solid, liquid and gas. The focus of University of Luxembourg PhD candidate Anjali Sharma’s research lies between solid and liquid: liquid crystal. She studies them in unusual shapes that are no larger than the width of a human hair, yet they are considered as large by the scientists of the field. As part of her research, the Indian national got an opportunity for a rare experiment: Taking her research into a zero gravity environment.

Spotlight on Young Researchers: How is scientific quality fostered by research collaboration?

In the last decades, how research is conducted has been profoundly changed by ICT, and there has also been a shift from the ‘sole genius’ towards teamwork and especially interdisciplinarity: Today, millions of researchers worldwide collaborate across organisational, disciplinary, and cultural boundaries, extending the possibilities of new scientific discovery. This, and the associated data, has paved the way for the scientific field Science of Science, where one key question is understanding exactly how scientific quality is fostered by research collaboration.

Spotlight on Young Researchers: Identifying environmental pollutants

Nobody is untouched by environmental chemical pollution, but most are unaware of how they are exposed, what to, and the possible health consequences. With over 350,000 registered chemicals in use, an important first step towards assessing their environmental impacts is to make chemical information more machine-readable and open. Environmental Cheminformatics is on the case.

Spotlight on Young Researchers: Taking disruptions into account in life cycle/sustainability assessment

Global supply networks are more complex than ever, and recent global events have shown how susceptible society is to unpredictable disturbances. Scientists are working to understand the effect disruptions have on the sustainability of productive systems with the goal to provide solutions to support decision-making.

Spotlight on Young Researchers: Amy Parrish

During her Master’s studies, Amy Parrish found her passion for research with a clinical aspect. Having come from London to Luxembourg to pursue her AFR PhD at the Luxembourg Institute of Health (LIH) in the research group of Mahesh Desai, the American national studies the bacteria that inhabit our gut, to shed light on the development of diseases such as Inflammatory Bowel Disease (IBD).

Spotlight on Young Researchers: Nature’s shapes as mathematical challenges

In nature, we see hyperbolic forms in corals, flatworms, and many other species of reef organisms, such as sponges and kelps. The hyperbolic spaces are also of interest for mathematicians, who are looking to prove the solvability of invariant systems of differential equations in unusual spaces such as these.

Spotlight on Young Researchers: Nathasia Mudiwa Muwanigwa

Growing up in Botswana and Zimbabwe, Nathasia Mudiwa Muwanigwa did not see science as a career option. Fast forward a few years: Nathasia is studying Parkinson’s disease as part of her PhD at the LCSB at the University of Luxembourg, and has co-founded a STEM initiative that was featured in Forbes.

Spotlight on Young Researchers: Kacy Greenhalgh

Kacy Greenhalgh has always had an affectation for medicine and health, and how health can be influenced by dietary habits. During her Master studies, the Luxembourg-American national was introduced to FNR ATTRACT Fellow Paul Wilmes and the ‘gut on a chip’, HuMiX. Fascinated by its potential, and how it could be used to study the relation between diet and health, Kacy’s curiosity led her straight to an AFR PhD at the LCSB at the University of Luxembourg.

Spotlight on Young Researchers: Thomas Schaubroeck

Thomas Schaubroeck specialises in sustainability assessment of products. We speak to the Belgian national about the research he is undertaking in the framework of an Industrial Fellowship between the Luxembourg Institute of Science and Technology (LIST) and company Tarkett; how working with industry differs from academia; and how he hopes his research can help industry steer toward a more sustainable future.

Spotlight on Young Researchers: Xianqing Mao

Xianqing Mao comes from a family of professors and doctors and thus has always had a natural interest in science. The Chinese national completed a medical degree, but felt she still had unanswered questions, so she decided to go abroad and took a leap into biomedical research. After stays in France, the UK, the United States and Belgium, Xianqing is now transitioning from junior to senior researcher at the Luxembourg Institute of Health, where she has already been involved in several projects investigating cancer progression.

Spotlight on Young Researchers: Gilles Tossing

Gilles Tossing’s fascination for the human brain – and why it sometimes fails – led him to the path of research. Now in the second year of his AFR PhD at Université de Montréal in Canada, the Luxembourg national investigates neurodegenerative diseases, with the aim of improving treatments for those affected.

Spotlight on Young Researchers: AI for ethical and legal debates

Looking at popular culture, big tech and ongoing societal debates – technological progress in Artificial Intelligence (AI) affects us all. Researchers from numerous scientific fields are working on the best way to bring AI forward, including the study of systems able to autonomously reason over arguments – calculators for philosophical, ethical or legal debates.

Spotlight on Young Researchers: Toward a risk assessment system for natural and biological systems

Is it possible to use mathematical indicators to alert about natural disasters and help in the early detection of disease and health issues? Over the past 15 years, scientists have been working on bridging mathematical theory and empirical evidence to do just that. To move the science forward, a key challenge is the underlying mathematical problem, as well as determining how the indicators should be applied.

Spotlight on Young Researchers: An algorithm to allocate satellite resources

When the first satellite was launched in the 1950s, earth orbit was a lonely place. Since then, more than 11,000 satellites have been launched into space and over 3,000 are still in operation. Estimates suggest an exponential increase in satellites in the next years, creating a challenge for the effective allocation of the needed bandwidth and power. Researchers are developing algorithms to more effectively allocate the resources where and when they are needed.

Spotlight on Young Researchers: Dark patterns and the battle to free the web from manipulation

Online services are designed to offer great user experiences and accommodate our needs. They can also use manipulative design strategies to push us to disclose our personal information, purchase goods and subscriptions or spend an excessive quantity of time on apps and games. Learn about ‘dark patterns’ and an interdisciplinary research effort to free the web from manipulation.

Spotlight on Young Researchers: Mohammad Zare

Floods across the world have resulted in tremendous economic damage and loss of lives: better tools to predict flood rise and recession are needed. The biggest question facing researchers like Mohammad Zare is how to accurately simulate and predict this complex phenomenon. As part of an Industrial Fellowship between the University of Luxembourg and company RSS-Hydro, the Postdoc Works on improving the simulation and prediction of flash floods, with the goal to develop a decision-making model for flood protection in Luxembourg.

Spotlight on Young Researchers: Neighbourhood characteristics as determinants of health

Unhealthy lifestyles – unbalanced diet and physical inactivity – are the main factor in the leading cause of death in the world: cardiometabolic disease. Our socioeconomic environment plays a role in these lifestyle choices. Over a 9-year period, researchers are looking at how socio-economic and physical environmental characteristics of residential neighbourhoods shape our physical activity, nutritional behaviour and cardiometabolic health.

Spotlight on Young Researchers: Zhe Liu

Zhe Liu’s passion for research grew from a desire to find out how things work and why. Considering himself as a ‘Luxembourg-made Chinese researcher’, Zhe came to Luxembourg in 2011 for his AFR PhD, a project for which he later won an FNR Award for ‘Outstanding PhD Thesis’ in 2016.

Spotlight on Young Researchers: Konstantinos Papadopoulos

During his computer science studies, Konstantinos Papadopoulos realised how many unexplored areas there are in the field and his desire for becoming a researcher was born. Now in the 2nd year of his PhD at the SnT at the University of Luxembourg, the Greek national works on developing innovative new approaches to security surveillance.

Spotlight on Young Researchers: Environmental factors and their role in Parkinson’s Disease

An estimated 10% of Parkinson’s Diseases cases are due to genetic factors – in the search for answers as to what could cause the other 90%, research is increasingly finding evidence pointing to environmental factors. To paint a clearer picture of what role chemicals could play in the disease, researchers are for example looking for ‘fingerprints’ of chemicals in biological samples.

Spotlight on Young Researchers: Pit Losch

Passion and competitiveness is at the heart of being a researcher for Pit Losch, who describes life in research as a rollercoaster ride. The Luxembourg national, who completed his AFR PhD at the University of Strasbourg, is currently a Postdoc at Max Planck Institute for Coal Research, where he investigates and shapes materials for the future. We spoke to Pit about his life as a scientist.

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