Spotlight on Young Researchers: Charles de Bourcy

 

Charles de Bourcy decided to become a researcher on human health when he realised the human body is not invincible. After completing his undergraduate studies at University of Oxford, the Luxembourg national secured one of the most prestigious scholarships in the world and embarked on a PhD at Stanford University. Now in the final year of this PhD in Applied Physics, Charles is taking his first steps towards his goal of building technologies to help ease the burden of global disease.

Charles de Bourcy’s job in his PhD has been to try to find aspects of the human immune system that can be engineered to prevent or treat life-threatening diseases.

“My PhD projects focus on how immune cells can go wrong in old age, how they can be affected by immunotherapy for systemic sclerosis, and how we might prevent cancer-fighting cells from falling into a dysfunctional ‘exhausted’ state”, Charles explains.

Charles adds that this involves using the latest advances in genomics technology, combined with high-performance computing and quantitative analytics.

“Early on, a lot of time might be spent preparing blood samples for DNA sequencing, which means pipetting reagents. Later on, I spend most of my time coding to carry out computational analysis. In the afternoons, I often meet with the collaborators to discuss progress or learn about advances from other research groups. In the final phase of a project, I spend my days writing and preparing figures for publication.”

“I was drawn to the profound impact a researcher can have”

Charles explains his passion for research was triggered by the realisation that the human body is not invincible – that there are infectious diseases, cancers, autoimmune diseases and more that still have extremely limited treatment options.

“This feeling of helplessness pushed me to work on problems in human health. I was drawn to the profound impact the work of a researcher can have: a single discovery can change the paradigm for how an entire class of diseases are handled.

“For example, synthetic biology has enabled engineered immune cells against tumors, which have the potential to improve outcomes for a whole range of different cancers.

“Part of the fun is that such breakthroughs often happen in indirect ways — there’s this saying that the light bulb wasn’t invented by someone trying to make a better candle.”

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable”

In terms of what Charles wants to achieve as a scientist, he explains that he wants to help reduce the global disease burden, by building technologies that enable diseases to be treated – or prevented – in the best possible way:

“My first step in this endeavor has been to develop tools that allow previously impenetrable aspects of immunology to be measured quantitatively.

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable – advances in genomics, image processing and machine learning could be used to great effect in medicine, particularly if leveraged at a large scale.

“For example, surveys of immune repertoires and viral evolution across the globe could lead to more efficacious vaccine development and allow epidemics to be managed better, before they develop into catastrophic pandemics.”

Charles left Luxembourg for his undergraduate studies at the University of Oxford in the UK, before moving to Stanford University in California for his PhD. Even though Charles has been away for some years, he has been keeping an eye on the research landscape in Luxembourg for his future scientific plans:

“I have been following the development of Luxembourg’s research infrastructure with excitement. The country is pouring a lot of resources into expanding its research activity, making it a very attractive place to launch ambitious projects.”

Charles is now finishing up his PhD in Applied Physics at Stanford University. Charles’ PhD was funded by the International Fulbright Science & Technology Award and by the Melvin and Joan Lane Stanford Graduate Fellowship.

Meeting Nobel Prize winners

Charles was one of 400 early-career scientists selected to attend 2015 Lindau Nobel Laureate Meeting, with his attendance sponsored by the FNR – read an interview with Charles about the experience.

Charles at the 2015 Lindau Nobel Laureate Meeting, here with Françoise Barré-Sinoussi, 2008 recipient of the Nobel Prize in Physiology or Medicine for the discovery of HIV.
Charles de Bourcy

About Spotlight on Young Researchers

Spotlight on Young Researchers is an FNR initiative to highlight early career researchers across the world who have a connection to Luxembourg. This article is the 17th in a series of around 25 articles, which will be published on a weekly basis. You can see more articles below as and when they are published.

Spotlight on Young Researchers: Paul Hauseux

Paul Hauseux was always interested in science, but only recently settled on the researcher path. Before that, his career ambitions stretched from working in sports or music to teaching science. Some years and a PhD later, the French national has come to Luxembourg for his computational engineering Postdoc in the team of ERC grantee Stéphane Bordas at the University of Luxembourg.

Spotlight on Young Researchers: Environmental factors and their role in Parkinson’s Disease

An estimated 10% of Parkinson’s Diseases cases are due to genetic factors – in the search for answers as to what could cause the other 90%, research is increasingly finding evidence pointing to environmental factors. To paint a clearer picture of what role chemicals could play in the disease, researchers are for example looking for ‘fingerprints’ of chemicals in biological samples.

Spotlight on Young Researchers: Jose-Luis Sanchez-Lopez

Jose-Luis Sanchez-Lopez works with multirotor aerial robots – drones. Despite being early in his research career, the Spanish national’s research is already taking off, having secured him several awards at international competitions. After completing his PhD in 2017, Jose-Luis set his sights on Luxembourg, where he works as a Postdoc at the SnT at the University of Luxembourg, with the goal of giving drones enough AI that they can safely operate autonomously in a range of environments.

Spotlight on Young Researchers: Maria Pires Pacheco

Maria Pires Pacheco is a problem solver with a fondness for coding, who was always drawn to the scientist in a group of heroes, rather than the classic hero. During her AFR PhD, the Luxembourg national worked on building tools that help simulate the metabolism of a cell, tools she applied to cancer research during her postdoc.

Spotlight on Young Researchers: Remko Nijzink

Climate change affects vegetation and water resources. In order to understand these changes, scientists use models – an abstract, mathematical representation of an ecological system. The challenge: Making accurate predictions under change, without ‘tuning’ models with data. We speak to Dutch national Remko Nijzink, Postdoc in the group of FNR ATTRACT Fellow Dr. Stan Schymanski at the Luxembourg Institute of Science and Technology (LIST), about his modelling work and the importance of an open science approach.

A system to support forest ecosystem decision-making

Industry and research join forces on many fronts, including the sustainable use of natural resources. Postdoc Claudio Petucco works on developing a decision support system for enhancing and assessing the provision of forest ecosystem services. The goal: improving the sustainable use of natural resources in Luxembourg.

Spotlight on Young Researchers: Dementia in neurodegeneration – defining the role of microglia, the brain’s immune cells

An estimated 55 million people in the world suffer from dementia, with the number estimated to increase to 78 million by 2030. In Luxembourg, more than 10,000 people suffer from dementia, including patients affected by Alzheimer’s disease and Dementia with Lewy Bodies. These incurable diseases have an increasing socio-economic impact along with the burden on patients and caregivers. One of the approaches researchers are taking is studying microglia, immune cells in the brain.

Spotlight on Young Researchers: Antoun Al Absi

Antoun Al Absi has been fascinated by microscopes ever since his parents gave him one as a child. Unsurprisingly, the Syrian-French national cherishes the long hours spent on the microscope as part of his AFR PhD at the Luxembourg Institute of Health (LIH), where he investigates how tumour cells escape the ‘immune surveillance system’, enabling them to spread to other parts of the body.

Spotlight on Young Researchers: Pit Ullmann

Pit Ullmann’s interest in natural sciences was piqued in high school. The Luxembourg national went on to study molecular biology at the University of Innsbruck and then found himself desiring a job that would be both interdisciplinary and diversified – fast forward and Pit is now completing his AFR PhD at the University of Luxembourg, where his research group studies why and how colon cancer develops and spreads.

Spotlight on Young Researchers – revisited 5 years later: From Luxembourg to Australia

When we wrote about Chetan Arora in the 2017 edition of Spotlight on Young Researchers, he was a Postdoc working in requirements engineering at the SnT, having just completed his PhD. 5 years later, Chetan is on the other side of the world working as a Senior Lecturer and Academic Director for coursework research. We spoke to Chetan about how he is still a “houfreg Lëtzebuerger”, what he is working on now, and why after working both in industry and academia, he found his heart to be in the world of research.

Spotlight on Young Researchers: A fully automatic flood mapping algorithm

Flooding presents a major hazard in both rural and urban areas. Luxembourg was also affected by the significant floods that devastated parts of Germany in July 2021. With the goal of predicting areas that will flood, scientists are working on various aspects of flood-mapping using satellite data.

Spotlight on Young Researchers: Identifying environmental pollutants

Nobody is untouched by environmental chemical pollution, but most are unaware of how they are exposed, what to, and the possible health consequences. With over 350,000 registered chemicals in use, an important first step towards assessing their environmental impacts is to make chemical information more machine-readable and open. Environmental Cheminformatics is on the case.

Spotlight on Young Researchers: Ramping up carbohydrates production

Carbs are all around us: a major constituent in food, they also play a role in many biological processes such as intercellular communication; they are in demand in the pharmaceutical industry, where they are currently used as anticoagulants and in skincare. With the goal of no longer having to rely solely on nature’s production of carbs, scientists have been working on ways to ramp up production. A case for chemistry!

Spotlight on Young Researchers: A hazelnut quality forecasting system

Can we predict the likelihood of a hazelnut tree becoming sick? Or what quality defects, and in what percentage, will be present in the final harvest? Science could soon make this possible, thanks to a hazelnut quality forecasting system based on a combination of machine learning and simulation models.

Spotlight on Young Researchers: Antonio Ancora

In the current situation of legal uncertainty, PhD candidate Antonio Ancora’s research at the University of Luxembourg aims to improve tax certainty in the context of state aid investigation on Transfer Pricing transactions among multinational enterprises.

Spotlight on Young Researchers: Neighbourhood characteristics as determinants of health

Unhealthy lifestyles – unbalanced diet and physical inactivity – are the main factor in the leading cause of death in the world: cardiometabolic disease. Our socioeconomic environment plays a role in these lifestyle choices. Over a 9-year period, researchers are looking at how socio-economic and physical environmental characteristics of residential neighbourhoods shape our physical activity, nutritional behaviour and cardiometabolic health.

Spotlight on Young Researchers: Turning up the heat on solar absorbers

Using solar absorbers for collection and storage of heat from the sun is an environmentally friendly way to generate heat, yet only 16% of heating is generated from renewable energy. Material scientists are looking for ways to boost this number by making the solar absorber coatings more efficient.

Spotlight on Young Researchers: A gas sensor powered by natural light

Many of the things we furnish our homes and office with emit gases that we are oblivious to inhaling. As eliminating these items from our lives is unrealistic, science wants to understand that which we cannot eliminate, thus more effective sensors are needed. Material scientist Rutuja Bhusari combines materials at nanoscale to create a gas sensor powered by nature.

Spotlight on Young Researchers: Dark patterns and the battle to free the web from manipulation

Online services are designed to offer great user experiences and accommodate our needs. They can also use manipulative design strategies to push us to disclose our personal information, purchase goods and subscriptions or spend an excessive quantity of time on apps and games. Learn about ‘dark patterns’ and an interdisciplinary research effort to free the web from manipulation.

Spotlight on Young Researchers: Isabel Z. Martínez

Isabel Z. Martínez has been interested in how policies are put in place and how they affect people’s lives for as long as she can remember. After completing her Masters in Economics, she realised that academia was the ideal way to quench her thirst for analysing large data sets and finding answers to questions addressing people’s well-being and policy decisions. The Swiss-Spanish national has been studying income and wealth inequality in Switzerland for years and has now come to Luxembourg as a Postdoc at LISER to expand her research to the Grand Duchy. We spoke to Isabel about life as a research economist, and how it has already enabled her to travel across the globe, as well as work with some of the foremost researchers in her field.

Spotlight on Young Researchers: Understanding drug resistance in skin cancer

Melanoma is a rare type of skin cancer, but it is the deadliest type – and incidence is on the rise. Metastatic melanoma has seen a rapid emergence in drug resistance: After a few months, treatment stops working and tumours begin to grow again. Molecular biologists are working to understand why this happens.

Spotlight on Young Researchers: Ramona Pelich

Ramona Pelich uses data from satellites in space to improve maritime surveillance and flood hazard monitoring. Splitting her time between the Luxembourg Institute of Science and Technology (LIST) and the company LuxSpace as part of her AFR-PPP Postdoc, the Romanian national’s work has already found direct application when flood maps she co-developed were used in the aftermath of destructive 2017 hurricanes Harvey and Irma.

Spotlight on Young Researchers: Adham Ayman Al-Sayyad

Adham Ayman Al-Sayyad is a PhD researcher working on multidisciplinary cross-border project. In our article, we explore the Egyptian national’s research around the topic of laser beam joining; why his next step post-PhD would be to spend some time working in industry to understand his research topic from new angles; and his passion for bridging cultures to bring people together.

Spotlight on Young Researchers: Paul Johanns

Paul Johanns works in a research field one does not read about every day: knots. As part of his AFR PhD at the École polytechnique fédérale de Lausanne (EPFL), the Luxembourg national combines high-precision model experiments, computation and theory to untangle the influence of topology on the mechanics of complex knots, particularly those used in surgical procedures.

Spotlight on Young Researchers: Eva Lagunas

Eva Lagunas has always been curious about technology, even building her own makeshift smartphone when she was a child. A couple of degrees later, the Spanish national set her sights on coming to Luxembourg, family in tow, to take up a Postdoc position at the University of Luxembourg’s Interdisciplinary Centre for Security, Reliability and Trust (SnT). Now, she feels lucky to spend her time researching satellite communications in the 5G era.

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