Spotlight on Young Researchers: Charles de Bourcy

 

Charles de Bourcy decided to become a researcher on human health when he realised the human body is not invincible. After completing his undergraduate studies at University of Oxford, the Luxembourg national secured one of the most prestigious scholarships in the world and embarked on a PhD at Stanford University. Now in the final year of this PhD in Applied Physics, Charles is taking his first steps towards his goal of building technologies to help ease the burden of global disease.

Charles de Bourcy’s job in his PhD has been to try to find aspects of the human immune system that can be engineered to prevent or treat life-threatening diseases.

“My PhD projects focus on how immune cells can go wrong in old age, how they can be affected by immunotherapy for systemic sclerosis, and how we might prevent cancer-fighting cells from falling into a dysfunctional ‘exhausted’ state”, Charles explains.

Charles adds that this involves using the latest advances in genomics technology, combined with high-performance computing and quantitative analytics.

“Early on, a lot of time might be spent preparing blood samples for DNA sequencing, which means pipetting reagents. Later on, I spend most of my time coding to carry out computational analysis. In the afternoons, I often meet with the collaborators to discuss progress or learn about advances from other research groups. In the final phase of a project, I spend my days writing and preparing figures for publication.”

“I was drawn to the profound impact a researcher can have”

Charles explains his passion for research was triggered by the realisation that the human body is not invincible – that there are infectious diseases, cancers, autoimmune diseases and more that still have extremely limited treatment options.

“This feeling of helplessness pushed me to work on problems in human health. I was drawn to the profound impact the work of a researcher can have: a single discovery can change the paradigm for how an entire class of diseases are handled.

“For example, synthetic biology has enabled engineered immune cells against tumors, which have the potential to improve outcomes for a whole range of different cancers.

“Part of the fun is that such breakthroughs often happen in indirect ways — there’s this saying that the light bulb wasn’t invented by someone trying to make a better candle.”

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable”

In terms of what Charles wants to achieve as a scientist, he explains that he wants to help reduce the global disease burden, by building technologies that enable diseases to be treated – or prevented – in the best possible way:

“My first step in this endeavor has been to develop tools that allow previously impenetrable aspects of immunology to be measured quantitatively.

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable – advances in genomics, image processing and machine learning could be used to great effect in medicine, particularly if leveraged at a large scale.

“For example, surveys of immune repertoires and viral evolution across the globe could lead to more efficacious vaccine development and allow epidemics to be managed better, before they develop into catastrophic pandemics.”

Charles left Luxembourg for his undergraduate studies at the University of Oxford in the UK, before moving to Stanford University in California for his PhD. Even though Charles has been away for some years, he has been keeping an eye on the research landscape in Luxembourg for his future scientific plans:

“I have been following the development of Luxembourg’s research infrastructure with excitement. The country is pouring a lot of resources into expanding its research activity, making it a very attractive place to launch ambitious projects.”

Charles is now finishing up his PhD in Applied Physics at Stanford University. Charles’ PhD was funded by the International Fulbright Science & Technology Award and by the Melvin and Joan Lane Stanford Graduate Fellowship.

Meeting Nobel Prize winners

Charles was one of 400 early-career scientists selected to attend 2015 Lindau Nobel Laureate Meeting, with his attendance sponsored by the FNR – read an interview with Charles about the experience.

Charles at the 2015 Lindau Nobel Laureate Meeting, here with Françoise Barré-Sinoussi, 2008 recipient of the Nobel Prize in Physiology or Medicine for the discovery of HIV.
Charles de Bourcy

About Spotlight on Young Researchers

Spotlight on Young Researchers is an FNR initiative to highlight early career researchers across the world who have a connection to Luxembourg. This article is the 17th in a series of around 25 articles, which will be published on a weekly basis. You can see more articles below as and when they are published.

Spotlight on Young Researchers: Michel Summer

For his AFR PhD at Trinity College Dublin, historian Michel Summer is re-assessing the political activity of medieval Anglo-Saxon missionary Willibrord, who in addition to being a landowner, scholar and ambassador, founded a monastery in Luxembourg. We spoke to the Luxembourg national about how history promotes critical thinking, and why he believes historians are needed more than ever.

Spotlight on Young Researchers: Svenja Bourone

Svenja Bourone is a chemist who has always had a fascination for natural sciences. During her master studies at RWTH Aachen, she became captivated by functional nanomaterials and as chance would have it, a doctoral position opened up in just that field. During her AFR PhD, Svenja developed a new protocol to help with the synthesisation of gold nanoparticles, which she is now putting to use in her work as a Postdoc. The Luxembourg national has a strong desire to return home to the Grand Duchy to continue her work on nanomaterials.

Spotlight on Young Researchers: Sebastian Scheer

Senior Postdoc Sebastian Scheer’s thirst for understanding how biological systems work led him to dive into the world of immunology research. After moving from Germany to Canada, the Luxembourg national got the chance to set up his group leader’s new lab in Australia, where his research revolves around the T cell, a key player in the shaping of immune responses.

Spotlight on Young Researchers: Nature’s shapes as mathematical challenges

In nature, we see hyperbolic forms in corals, flatworms, and many other species of reef organisms, such as sponges and kelps. The hyperbolic spaces are also of interest for mathematicians, who are looking to prove the solvability of invariant systems of differential equations in unusual spaces such as these.

A system to support forest ecosystem decision-making

Industry and research join forces on many fronts, including the sustainable use of natural resources. Postdoc Claudio Petucco works on developing a decision support system for enhancing and assessing the provision of forest ecosystem services. The goal: improving the sustainable use of natural resources in Luxembourg.

Spotlight on Young Researchers: The human gut microbiome and the clues it holds

Research is steadily painting a picture revealing the significance the human gut microbiome plays in health and disease. From gastrointestinal tract disorders to the beginnings and treatment of Parkinson’s disease and beyond, the gut microbiome is a treasure trove of clues for researchers. We speak to three women in science – a biomedical scientist, a microbiologist and a bioscience engineer – about organs-on-chips and restoring an imbalanced microbiome.

Spotlight on Young Researchers: Collecting individual and personal stories of the war generation in Luxembourg

Over 10,000 Luxembourgish women and men wore German uniforms during WWII in armed forces and civil organisations – many were drafted by the Nazi German authorities – and behind each name is a story waiting to be told. A team of researchers has been working with families in Luxembourg to piece together the personal stories of the war generation in Luxembourg.

Spotlight on Young Researchers: Dimitra Anastasiou

In 2015, Dimitra Anastasiou was featured in our campaign ‘Spotlight on Young Researchers’, which highlighted early-career researchers with a connection to Luxembourg. In November 2015, Dimitra moved to Luxembourg with her young family to start her prestigious Marie Curie Individual Fellowship at the Luxembourg Institute of Science and Technology (LIST). One year on, we caught up with Dimitra!

Spotlight on Young Researchers: Michel Thill

For his part-time AFR PhD in Political Science with Ghent University’s Conflict Research Group, Michel Thill researches a little-studied subject: everyday policing practices and interactions between police and people in Bukavu, a provincial capital in the East of the Democratic Republic of Congo. We spoke to the Luxembourg national about insatiable curiosity being a virtue for researchers; the experiences gained during his PhD; and why his research subject is important.

Spotlight on Young Researchers: Gil Georges

Gil Georges is driven by the quest for knowledge and strives to have a real impact, beyond publications. The Luxembourg national has just made the jump from early-career researcher to lecturer and group leader at the IET-LAV at ETH Zürich in Switzerland, where the data analyst and modeller gets to use one of Europe’s most powerful super computers when it is time for some serious number crunching.

Spotlight on Young Researchers: Jo Hoeser

Ever since he was a child, Jo Hoeser wanted to understand the function of complex systems. He found himself taking apart and trying to fix broken electronic devices. Then fascination for chemistry came into the mix. Fast forward some years and the Luxembourg national completed his AFR PhD in biochemistry at the Albert-Ludwigs University Freiburg – and wants to return to the Grand Duchy to continue his career in research.

Spotlight on Young Researchers – revisited 5 years later: From drones to space robotics

When we wrote about Miguel Olivares Mendez in the 2017 edition of Spotlight on Young Researchers, the researcher was working on an FNR JUMP project, focussing on developing algorithms for autonomous drones. The robotics scientist has continued to build his research career in Luxembourg – 5 years later, Miguel is a Professor leading a research group with a focus on space robotics.

Spotlight on Young Researchers: Mohammad Zare

Floods across the world have resulted in tremendous economic damage and loss of lives: better tools to predict flood rise and recession are needed. The biggest question facing researchers like Mohammad Zare is how to accurately simulate and predict this complex phenomenon. As part of an Industrial Fellowship between the University of Luxembourg and company RSS-Hydro, the Postdoc Works on improving the simulation and prediction of flash floods, with the goal to develop a decision-making model for flood protection in Luxembourg.

Spotlight on Young Researchers: Neighbourhood characteristics as determinants of health

Unhealthy lifestyles – unbalanced diet and physical inactivity – are the main factor in the leading cause of death in the world: cardiometabolic disease. Our socioeconomic environment plays a role in these lifestyle choices. Over a 9-year period, researchers are looking at how socio-economic and physical environmental characteristics of residential neighbourhoods shape our physical activity, nutritional behaviour and cardiometabolic health.

Spotlight on Young Researchers: Remko Nijzink

Climate change affects vegetation and water resources. In order to understand these changes, scientists use models – an abstract, mathematical representation of an ecological system. The challenge: Making accurate predictions under change, without ‘tuning’ models with data. We speak to Dutch national Remko Nijzink, Postdoc in the group of FNR ATTRACT Fellow Dr. Stan Schymanski at the Luxembourg Institute of Science and Technology (LIST), about his modelling work and the importance of an open science approach.

Spotlight on Young Researchers: Anjali Sharma

In school, we are taught three states of matter: solid, liquid and gas. The focus of University of Luxembourg PhD candidate Anjali Sharma’s research lies between solid and liquid: liquid crystal. She studies them in unusual shapes that are no larger than the width of a human hair, yet they are considered as large by the scientists of the field. As part of her research, the Indian national got an opportunity for a rare experiment: Taking her research into a zero gravity environment.

Spotlight on Young Researchers: Guillaume Nataf

“Would matter be perfect, it would be boring” says Guillaume Nataf, who has an oozing passion for physics and teaching fundamental science. The French national did his PhD in the group of FNR PEARL Chair Jens Kreisel at the Luxembourg Institute of Science and Technology (LIST), in collaboration with the French Atomic Commission (CEA). We spoke to Guillaume, who has just started a Postdoc at the University of Cambridge, about life as a researcher.

Spotlight on Young Researchers: Isabel Z. Martínez

Isabel Z. Martínez has been interested in how policies are put in place and how they affect people’s lives for as long as she can remember. After completing her Masters in Economics, she realised that academia was the ideal way to quench her thirst for analysing large data sets and finding answers to questions addressing people’s well-being and policy decisions. The Swiss-Spanish national has been studying income and wealth inequality in Switzerland for years and has now come to Luxembourg as a Postdoc at LISER to expand her research to the Grand Duchy. We spoke to Isabel about life as a research economist, and how it has already enabled her to travel across the globe, as well as work with some of the foremost researchers in her field.

Spotlight on Young Researchers: Glioblastoma and the challenge of getting cancer drugs to reach the brain

Glioblastoma is the most aggressive form of brain tumours in adults. The incidence is about 4 per 100.000 people and the average survival after diagnosis is about 14 months with current treatments. The tumour’s location represents a major challenge – few drugs make it past the blood brain barrier. Researchers are working on designing a novel kind of drug that could help do just that.

Spotlight on Young Researchers: Nina Hentzen

Nina Hentzen, an organic chemist working on the chemical synthesis of collagen, is fascinated by research at the interface of chemistry and biology. The Luxembourg national is in the second year of her AFR PhD at ETH Zürich – and has just been selected to attend the renowned 2017 Lindau Nobel Laureate Meeting.

Spotlight on Young Researchers: Noémie Catherine Engel

Noémie Catherine Engel has just begun her researcher journey – and she has found her niche already: As part of her AFR PhD at the University of Bath, the Luxembourg national investigates the evolution of sex role traits in a small shorebird species in Cape Verde.

Spotlight on Young Researchers: Steve Dias Da Cruz

While machine learning and deep learning have come a long way, they are not yet at a stage where autonomous vehicles can handle unexpected situations. As part of a public research-industry collaboration, early career researcher Steve Dias Da Cruz investigates possibilities to reduce the amount of data needed to train reliable deep learning models for safety critical applications in the automotive industry.

Spotlight on Young Researchers: Pier Mario Lupinu

When one thinks of banks and financial institutions, the word ‘research’ may not come to mind. However, research has much to offer these institutions, for example new tools to help with delivering critical services. As part of his PhD at the University of Luxembourg, Italian national Pier Mario Lupinu researches issues related to post-resolution in banking and finance.

Spotlight on Young Researchers: Lucas Oesch

Luxembourg is one of many countries experiencing the arrival of asylum seekers and refugees that have been displaced for reasons such as conflicts or instability in their own country. Managing a research team for the first time, CORE Junior PI Lucas Oesch leads the project ‘REFUGOV’ at the University of Luxembourg, which looks at the accommodation of asylum seekers and refugees in cities and camps.

Spotlight on Young Researchers – revisited 5 years later: A post-PhD life in finance

When Eric Finn Schaanning was featured in Spotlight on Young Researchers in 2017, he had just defended his AFR PhD on fire sales and systemic risk in financial networks at Imperial College London. In 2017, Eric attended the Lindau Nobel Laureate Meeting and in 2018, won an FNR Award for his PhD thesis. 5 years after his PhD, we catch up with Eric, who has been working on cyber risks, financial and regulatory stress tests as well operational risk management – a career spanning Norway, Frankfurt and Zürich – and reflect on the value his PhD has added.

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