Spotlight on Young Researchers: Charles de Bourcy

 

Charles de Bourcy decided to become a researcher on human health when he realised the human body is not invincible. After completing his undergraduate studies at University of Oxford, the Luxembourg national secured one of the most prestigious scholarships in the world and embarked on a PhD at Stanford University. Now in the final year of this PhD in Applied Physics, Charles is taking his first steps towards his goal of building technologies to help ease the burden of global disease.

Charles de Bourcy’s job in his PhD has been to try to find aspects of the human immune system that can be engineered to prevent or treat life-threatening diseases.

“My PhD projects focus on how immune cells can go wrong in old age, how they can be affected by immunotherapy for systemic sclerosis, and how we might prevent cancer-fighting cells from falling into a dysfunctional ‘exhausted’ state”, Charles explains.

Charles adds that this involves using the latest advances in genomics technology, combined with high-performance computing and quantitative analytics.

“Early on, a lot of time might be spent preparing blood samples for DNA sequencing, which means pipetting reagents. Later on, I spend most of my time coding to carry out computational analysis. In the afternoons, I often meet with the collaborators to discuss progress or learn about advances from other research groups. In the final phase of a project, I spend my days writing and preparing figures for publication.”

“I was drawn to the profound impact a researcher can have”

Charles explains his passion for research was triggered by the realisation that the human body is not invincible – that there are infectious diseases, cancers, autoimmune diseases and more that still have extremely limited treatment options.

“This feeling of helplessness pushed me to work on problems in human health. I was drawn to the profound impact the work of a researcher can have: a single discovery can change the paradigm for how an entire class of diseases are handled.

“For example, synthetic biology has enabled engineered immune cells against tumors, which have the potential to improve outcomes for a whole range of different cancers.

“Part of the fun is that such breakthroughs often happen in indirect ways — there’s this saying that the light bulb wasn’t invented by someone trying to make a better candle.”

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable”

In terms of what Charles wants to achieve as a scientist, he explains that he wants to help reduce the global disease burden, by building technologies that enable diseases to be treated – or prevented – in the best possible way:

“My first step in this endeavor has been to develop tools that allow previously impenetrable aspects of immunology to be measured quantitatively.

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable – advances in genomics, image processing and machine learning could be used to great effect in medicine, particularly if leveraged at a large scale.

“For example, surveys of immune repertoires and viral evolution across the globe could lead to more efficacious vaccine development and allow epidemics to be managed better, before they develop into catastrophic pandemics.”

Charles left Luxembourg for his undergraduate studies at the University of Oxford in the UK, before moving to Stanford University in California for his PhD. Even though Charles has been away for some years, he has been keeping an eye on the research landscape in Luxembourg for his future scientific plans:

“I have been following the development of Luxembourg’s research infrastructure with excitement. The country is pouring a lot of resources into expanding its research activity, making it a very attractive place to launch ambitious projects.”

Charles is now finishing up his PhD in Applied Physics at Stanford University. Charles’ PhD was funded by the International Fulbright Science & Technology Award and by the Melvin and Joan Lane Stanford Graduate Fellowship.

Meeting Nobel Prize winners

Charles was one of 400 early-career scientists selected to attend 2015 Lindau Nobel Laureate Meeting, with his attendance sponsored by the FNR – read an interview with Charles about the experience.

Charles at the 2015 Lindau Nobel Laureate Meeting, here with Françoise Barré-Sinoussi, 2008 recipient of the Nobel Prize in Physiology or Medicine for the discovery of HIV.
Charles de Bourcy

About Spotlight on Young Researchers

Spotlight on Young Researchers is an FNR initiative to highlight early career researchers across the world who have a connection to Luxembourg. This article is the 17th in a series of around 25 articles, which will be published on a weekly basis. You can see more articles below as and when they are published.

Spotlight on Young Researchers: Amy Parrish

During her Master’s studies, Amy Parrish found her passion for research with a clinical aspect. Having come from London to Luxembourg to pursue her AFR PhD at the Luxembourg Institute of Health (LIH) in the research group of Mahesh Desai, the American national studies the bacteria that inhabit our gut, to shed light on the development of diseases such as Inflammatory Bowel Disease (IBD).

Spotlight on Young Researchers: Paul Hauseux

Paul Hauseux was always interested in science, but only recently settled on the researcher path. Before that, his career ambitions stretched from working in sports or music to teaching science. Some years and a PhD later, the French national has come to Luxembourg for his computational engineering Postdoc in the team of ERC grantee Stéphane Bordas at the University of Luxembourg.

Spotlight on Young Researchers: Max Hilaire Wolter

During his Bachelor studies in physics and photovoltaics at the University of Luxembourg, Max Hilaire Wolter was exposed to live-action research for the first time. The experience left such a positive impression that Max proactively sought out to return to the same lab for a PhD after completing his Master’s studies abroad. We spoke to the Luxembourg national about why research is fun, solar cells and the importance of science outreach.

Spotlight on Young Researchers: Adham Ayman Al-Sayyad

Adham Ayman Al-Sayyad is a PhD researcher working on multidisciplinary cross-border project. In our article, we explore the Egyptian national’s research around the topic of laser beam joining; why his next step post-PhD would be to spend some time working in industry to understand his research topic from new angles; and his passion for bridging cultures to bring people together.

Spotlight on Young Researchers: Maxime Brami

Archaeologist and trained anthropologist Maxime Brami works on uncovering the origins and spread of agriculture, and has just landed a sought-after Marie Skłodowska-Curie Individual Fellowship. We speak to the Luxembourg national about what it’s like to be an archaeologist in academia, the collaborative nature of the field and why archaeologists have a certain responsibility.

Spotlight on Young Researchers: Laurie Maldonado

Laurie Maldonado’s research focuses on single-parent families. After suddenly becoming a single parent herself, she experienced first-hand how quickly single-parent families can fall into poverty in the United States, not knowing if she could continue her research. Then Laurie secured an AFR PhD grant, conducting her research at the LIS Cross-National Data Center in Luxembourg and at UCLA. A few years and a successful PhD defence later, we talked with Laurie about her journey and her close-to-home research.

Spotlight on Young Researchers: Foni Raphaël Lebrun-Ricalens

Quantum computing is one of the hottest topics in physical sciences. As part of his AFR PhD at the University of Sussex, Luxembourg national Foni Raphaël Lebrun-Ricalens works on developing a quantum computer – a technology that has the potential to revolutionise computing. Recently, he was also asked to evaluate the science behind the ‘quantum realm’ in the final ‘Avengers’ film.

Spotlight on Young Researchers: Pit Losch

Passion and competitiveness is at the heart of being a researcher for Pit Losch, who describes life in research as a rollercoaster ride. The Luxembourg national, who completed his AFR PhD at the University of Strasbourg, is currently a Postdoc at Max Planck Institute for Coal Research, where he investigates and shapes materials for the future. We spoke to Pit about his life as a scientist.

Spotlight on Young Researchers: Svenja Bourone

Svenja Bourone is a chemist who has always had a fascination for natural sciences. During her master studies at RWTH Aachen, she became captivated by functional nanomaterials and as chance would have it, a doctoral position opened up in just that field. During her AFR PhD, Svenja developed a new protocol to help with the synthesisation of gold nanoparticles, which she is now putting to use in her work as a Postdoc. The Luxembourg national has a strong desire to return home to the Grand Duchy to continue her work on nanomaterials.

Spotlight on Young Researchers: Empowering critical digital humanities practice

Digitisation has had a significant impact on humanities research: not only has it changed how many scholars conduct their research, it has also led to completely new fields of research, such as digital humanities, a highly interdisciplinary science. Linguist Lorella Viola is interested in how software can enable critical digital humanities practice.

Spotlight on Young Researchers: Collecting individual and personal stories of the war generation in Luxembourg

Over 10,000 Luxembourgish women and men wore German uniforms during WWII in armed forces and civil organisations – many were drafted by the Nazi German authorities – and behind each name is a story waiting to be told. A team of researchers has been working with families in Luxembourg to piece together the personal stories of the war generation in Luxembourg.

Spotlight on Young Researchers: Nina Hentzen

Nina Hentzen, an organic chemist working on the chemical synthesis of collagen, is fascinated by research at the interface of chemistry and biology. The Luxembourg national is in the second year of her AFR PhD at ETH Zürich – and has just been selected to attend the renowned 2017 Lindau Nobel Laureate Meeting.

Spotlight on Young Researchers: Toward a risk assessment system for natural and biological systems

Is it possible to use mathematical indicators to alert about natural disasters and help in the early detection of disease and health issues? Over the past 15 years, scientists have been working on bridging mathematical theory and empirical evidence to do just that. To move the science forward, a key challenge is the underlying mathematical problem, as well as determining how the indicators should be applied.

Spotlight on Young Researchers: Gilles Tossing

Gilles Tossing’s fascination for the human brain – and why it sometimes fails – led him to the path of research. Now in the second year of his AFR PhD at Université de Montréal in Canada, the Luxembourg national investigates neurodegenerative diseases, with the aim of improving treatments for those affected.

Spotlight on Young Researchers: Isabel Z. Martínez

Isabel Z. Martínez has been interested in how policies are put in place and how they affect people’s lives for as long as she can remember. After completing her Masters in Economics, she realised that academia was the ideal way to quench her thirst for analysing large data sets and finding answers to questions addressing people’s well-being and policy decisions. The Swiss-Spanish national has been studying income and wealth inequality in Switzerland for years and has now come to Luxembourg as a Postdoc at LISER to expand her research to the Grand Duchy. We spoke to Isabel about life as a research economist, and how it has already enabled her to travel across the globe, as well as work with some of the foremost researchers in her field.

Spotlight on Young Researchers – revisited 5 years later: A post-PhD life in finance

When Eric Finn Schaanning was featured in Spotlight on Young Researchers in 2017, he had just defended his AFR PhD on fire sales and systemic risk in financial networks at Imperial College London. In 2017, Eric attended the Lindau Nobel Laureate Meeting and in 2018, won an FNR Award for his PhD thesis. 5 years after his PhD, we catch up with Eric, who has been working on cyber risks, financial and regulatory stress tests as well operational risk management – a career spanning Norway, Frankfurt and Zürich – and reflect on the value his PhD has added.

Spotlight on Young Researchers: Understanding drug resistance in skin cancer

Melanoma is a rare type of skin cancer, but it is the deadliest type – and incidence is on the rise. Metastatic melanoma has seen a rapid emergence in drug resistance: After a few months, treatment stops working and tumours begin to grow again. Molecular biologists are working to understand why this happens.

Spotlight on Young Researchers: German Castignani

After doing his Master’s degree and working in the private sector in Argentina, German Castignani decided to do a research internship in France, which piqued his interest for research. After completing his PhD in wireless networking in France, the Italian-Argentinian national came to Luxembourg, where he added an entrepreneurial perspective to his vehicular telematics research, co-founding the SnT’s first spin-off Motion-S.

Spotlight on Young Researchers: Understanding how language manifests in the brain

At KU Leuven, Luxembourg national Jill Kries is part of a research team driven by understanding how cognition and brain structure develop over time in language-related disorders and how this knowledge can be applied in a clinical or educational setting. We take a closer look at the work of the young team.

Spotlight on Young Researchers: Konstantinos Papadopoulos

During his computer science studies, Konstantinos Papadopoulos realised how many unexplored areas there are in the field and his desire for becoming a researcher was born. Now in the 2nd year of his PhD at the SnT at the University of Luxembourg, the Greek national works on developing innovative new approaches to security surveillance.

Spotlight on Young Researchers: Multiple nationalities, one goal

What do a French, a Spanish, a Brazilian and an Algerian researcher have in common? In the case of Adeline Boileau, Antonio Salgado Somoza, Clarissa P. C. Gomes and Torkia Lalem, it’s that they are all early-career researchers who came to Luxembourg to join forces in the Cardiovascular Research Unit (CVRU) at the Luxembourg Institute of Health (LIH), which aims to identify new personalised strategies to diagnose and treat cardiovascular disease.

Spotlight on Young Researchers: Understanding our immune system

Stemming from Italy, Indonesia, Luxembourg, Portugal and Spain, the members of the Experimental & Molecular Immunology Group truly are an international team. In the group of FNR ATTRACT Fellow Prof Dr Dirk Brenner at the Luxembourg Institute of Health (LIH), the team of young researchers investigates different aspects of the immune system with one common goal: Understanding how our immune system is regulated by different mechanisms – and how this knowledge can be used to combat disease.

Spotlight on Young Researchers: Xianqing Mao

Xianqing Mao comes from a family of professors and doctors and thus has always had a natural interest in science. The Chinese national completed a medical degree, but felt she still had unanswered questions, so she decided to go abroad and took a leap into biomedical research. After stays in France, the UK, the United States and Belgium, Xianqing is now transitioning from junior to senior researcher at the Luxembourg Institute of Health, where she has already been involved in several projects investigating cancer progression.

Spotlight on Young Researchers: Thomas Schaubroeck

Thomas Schaubroeck specialises in sustainability assessment of products. We speak to the Belgian national about the research he is undertaking in the framework of an Industrial Fellowship between the Luxembourg Institute of Science and Technology (LIST) and company Tarkett; how working with industry differs from academia; and how he hopes his research can help industry steer toward a more sustainable future.

Spotlight on Young Researchers: The historical relationship between the European Community and the Soviet Union

As war rages in Ukraine, the topic PhD candidate Claude Ewert has been researching for the past three years is perhaps more relevant now than ever: the relationship between the European Community and the Soviet Union. The historian is gathering valuable information on the EC’s early foreign policy and the obstacles that had to be overcome to try to make the Community speak with one voice.

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