Charles de Bourcy decided to become a researcher on human health when he realised the human body is not invincible. After completing his undergraduate studies at University of Oxford, the Luxembourg national secured one of the most prestigious scholarships in the world and embarked on a PhD at Stanford University. Now in the final year of this PhD in Applied Physics, Charles is taking his first steps towards his goal of building technologies to help ease the burden of global disease.
Charles de Bourcy’s job in his PhD has been to try to find aspects of the human immune system that can be engineered to prevent or treat life-threatening diseases.
“My PhD projects focus on how immune cells can go wrong in old age, how they can be affected by immunotherapy for systemic sclerosis, and how we might prevent cancer-fighting cells from falling into a dysfunctional ‘exhausted’ state”, Charles explains.
Charles adds that this involves using the latest advances in genomics technology, combined with high-performance computing and quantitative analytics.
“Early on, a lot of time might be spent preparing blood samples for DNA sequencing, which means pipetting reagents. Later on, I spend most of my time coding to carry out computational analysis. In the afternoons, I often meet with the collaborators to discuss progress or learn about advances from other research groups. In the final phase of a project, I spend my days writing and preparing figures for publication.”
“I was drawn to the profound impact a researcher can have”
Charles explains his passion for research was triggered by the realisation that the human body is not invincible – that there are infectious diseases, cancers, autoimmune diseases and more that still have extremely limited treatment options.
“This feeling of helplessness pushed me to work on problems in human health. I was drawn to the profound impact the work of a researcher can have: a single discovery can change the paradigm for how an entire class of diseases are handled.
“For example, synthetic biology has enabled engineered immune cells against tumors, which have the potential to improve outcomes for a whole range of different cancers.
“Part of the fun is that such breakthroughs often happen in indirect ways — there’s this saying that the light bulb wasn’t invented by someone trying to make a better candle.”
“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable”
In terms of what Charles wants to achieve as a scientist, he explains that he wants to help reduce the global disease burden, by building technologies that enable diseases to be treated – or prevented – in the best possible way:
“My first step in this endeavor has been to develop tools that allow previously impenetrable aspects of immunology to be measured quantitatively.
“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable – advances in genomics, image processing and machine learning could be used to great effect in medicine, particularly if leveraged at a large scale.
“For example, surveys of immune repertoires and viral evolution across the globe could lead to more efficacious vaccine development and allow epidemics to be managed better, before they develop into catastrophic pandemics.”
Charles left Luxembourg for his undergraduate studies at the University of Oxford in the UK, before moving to Stanford University in California for his PhD. Even though Charles has been away for some years, he has been keeping an eye on the research landscape in Luxembourg for his future scientific plans:
“I have been following the development of Luxembourg’s research infrastructure with excitement. The country is pouring a lot of resources into expanding its research activity, making it a very attractive place to launch ambitious projects.”
Charles is now finishing up his PhD in Applied Physics at Stanford University. Charles’ PhD was funded by the International Fulbright Science & Technology Award and by the Melvin and Joan Lane Stanford Graduate Fellowship.
Meeting Nobel Prize winners
Charles was one of 400 early-career scientists selected to attend 2015 Lindau Nobel Laureate Meeting, with his attendance sponsored by the FNR – read an interview with Charles about the experience.
About Spotlight on Young Researchers
Spotlight on Young Researchers is an FNR initiative to highlight early career researchers across the world who have a connection to Luxembourg. This article is the 17th in a series of around 25 articles, which will be published on a weekly basis. You can see more articles below as and when they are published.
Spotlight on Young Researchers: Pier Mario Lupinu
When one thinks of banks and financial institutions, the word ‘research’ may not come to mind. However, research has much to offer these institutions, for example new tools to help with delivering critical services. As part of his PhD at the University of Luxembourg, Italian national Pier Mario Lupinu researches issues related to post-resolution in banking and finance.
Spotlight on Young Researchers: Improving how industrial plants are engineered
Current engineering systems have an issue: It is fragmented – process, Piping and structural design are carried out by separate teams and involves an error-prone exchange of data. A research collaboration involving public research and industry is tackling this issue by creating a unique central data hub of a plant to which all teams have access, with promising effects on efficiency.
Spotlight on Young Researchers: Towards predicting ageing-related diseases
A rapid increase in both life expectancy and global population size has led to a rise in the prevalence of chronic ageing-associated diseases. Brain and heart age-associated diseases including hypertension, stroke, heart failure, Alzheimer’s and Parkinson’s diseases are leading causes of mortality and disability worldwide. Researchers are working on much-needed ways to predict these diseases.
Spotlight on Young Researchers: Adham Ayman Al-Sayyad
Adham Ayman Al-Sayyad is a PhD researcher working on multidisciplinary cross-border project. In our article, we explore the Egyptian national’s research around the topic of laser beam joining; why his next step post-PhD would be to spend some time working in industry to understand his research topic from new angles; and his passion for bridging cultures to bring people together.
Spotlight on Young Researchers: Understanding brain mechanisms behind eating disorders
Eating disorders affect up to 5% of people. At the University of Luxembourg, Dr Annika Lutz and Lynn Erpelding study the brain mechanisms that help form body image, and want to understand how eating disorders develop. Using a multidimensional approach, the team’s ultimate goal is to improve treatment for people suffering from eating disorders, such as anorexia nervosa.
Spotlight on Young Researchers: Nathasia Mudiwa Muwanigwa
Growing up in Botswana and Zimbabwe, Nathasia Mudiwa Muwanigwa did not see science as a career option. Fast forward a few years: Nathasia is studying Parkinson’s disease as part of her PhD at the LCSB at the University of Luxembourg, and has co-founded a STEM initiative that was featured in Forbes.
Spotlight on Young Researchers: Nanotechnology – a future big player in health
Divya Balakrishnan, Dipti Rani and Serena Rollo are women in science working in a field that could have a major impact on how health is managed: In the group of FNR ATTRACT Fellow César Pascual García at the Luxembourg Institute of Science and Technology (LIST), the team works on developing sensors for biochemical applications focusing on medicine.
Spotlight on Young Researchers: Jose-Luis Sanchez-Lopez
Jose-Luis Sanchez-Lopez works with multirotor aerial robots – drones. Despite being early in his research career, the Spanish national’s research is already taking off, having secured him several awards at international competitions. After completing his PhD in 2017, Jose-Luis set his sights on Luxembourg, where he works as a Postdoc at the SnT at the University of Luxembourg, with the goal of giving drones enough AI that they can safely operate autonomously in a range of environments.
Spotlight on Young Researchers: Paul Johanns
Paul Johanns works in a research field one does not read about every day: knots. As part of his AFR PhD at the École polytechnique fédérale de Lausanne (EPFL), the Luxembourg national combines high-precision model experiments, computation and theory to untangle the influence of topology on the mechanics of complex knots, particularly those used in surgical procedures.
Spotlight on Young Researchers: Taking disruptions into account in life cycle/sustainability assessment
Global supply networks are more complex than ever, and recent global events have shown how susceptible society is to unpredictable disturbances. Scientists are working to understand the effect disruptions have on the sustainability of productive systems with the goal to provide solutions to support decision-making.
Spotlight on Young Researchers: Environmental factors and their role in Parkinson’s Disease
An estimated 10% of Parkinson’s Diseases cases are due to genetic factors – in the search for answers as to what could cause the other 90%, research is increasingly finding evidence pointing to environmental factors. To paint a clearer picture of what role chemicals could play in the disease, researchers are for example looking for ‘fingerprints’ of chemicals in biological samples.
Spotlight on Young Researchers: Lucas Oesch
Luxembourg is one of many countries experiencing the arrival of asylum seekers and refugees that have been displaced for reasons such as conflicts or instability in their own country. Managing a research team for the first time, CORE Junior PI Lucas Oesch leads the project ‘REFUGOV’ at the University of Luxembourg, which looks at the accommodation of asylum seekers and refugees in cities and camps.
Spotlight on Young Researchers: Harnessing the potential of the Internet of Things and satellites to make smart agriculture a reality
Lack of access to fast and reliable Internet in rural and remote areas is a [multi-step] challenge that must be addressed to pave the way for smart agriculture and precision farming, a vital step toward ensuring food security in a changing climate. In the quest for smart agriculture, researchers are working on solutions for connecting Internet of Things (IoT) with satellite communication (SATCOM) systems.
Spotlight on Young Researchers: Max Hilaire Wolter
During his Bachelor studies in physics and photovoltaics at the University of Luxembourg, Max Hilaire Wolter was exposed to live-action research for the first time. The experience left such a positive impression that Max proactively sought out to return to the same lab for a PhD after completing his Master’s studies abroad. We spoke to the Luxembourg national about why research is fun, solar cells and the importance of science outreach.
Spotlight on Young Researchers: Understanding how language manifests in the brain
At KU Leuven, Luxembourg national Jill Kries is part of a research team driven by understanding how cognition and brain structure develop over time in language-related disorders and how this knowledge can be applied in a clinical or educational setting. We take a closer look at the work of the young team.
Spotlight on Young Researchers: Damien Brevers
Postdoc Damien Brevers has a passion for studying self-control abilities in humans. Having spent time in Belgium and the US building expertise in areas including clinical psychology, sport psychology and brain imaging, the Belgian national has just joined the University of Luxembourg and embarked on a project looking at gambling addiction in the age of online betting.
Spotlight on Young Researchers – revisited 5 years later: From Luxembourg to Australia
When we wrote about Chetan Arora in the 2017 edition of Spotlight on Young Researchers, he was a Postdoc working in requirements engineering at the SnT, having just completed his PhD. 5 years later, Chetan is on the other side of the world working as a Senior Lecturer and Academic Director for coursework research. We spoke to Chetan about how he is still a “houfreg Lëtzebuerger”, what he is working on now, and why after working both in industry and academia, he found his heart to be in the world of research.
Spotlight on Young Researchers: Membranes for clean water
As the global population sharply increases, so does the demand for clean water. At the same time, freshwater is gradually being depleted. Combine these two factors, and we have the potential for widespread water shortages – it is estimated that half of European basins will be experiencing water stress by 2030, and that 6 billion people will suffer from clean water scarcity by 2050. Researchers are working on cost-effective practices to address this impending crisis.
Spotlight on Young Researchers: Multiple nationalities, one goal
What do a French, a Spanish, a Brazilian and an Algerian researcher have in common? In the case of Adeline Boileau, Antonio Salgado Somoza, Clarissa P. C. Gomes and Torkia Lalem, it’s that they are all early-career researchers who came to Luxembourg to join forces in the Cardiovascular Research Unit (CVRU) at the Luxembourg Institute of Health (LIH), which aims to identify new personalised strategies to diagnose and treat cardiovascular disease.
Spotlight on Young Researchers: The human gut microbiome and the clues it holds
Research is steadily painting a picture revealing the significance the human gut microbiome plays in health and disease. From gastrointestinal tract disorders to the beginnings and treatment of Parkinson’s disease and beyond, the gut microbiome is a treasure trove of clues for researchers. We speak to three women in science – a biomedical scientist, a microbiologist and a bioscience engineer – about organs-on-chips and restoring an imbalanced microbiome.
Spotlight on Young Researchers: The historical relationship between the European Community and the Soviet Union
As war rages in Ukraine, the topic PhD candidate Claude Ewert has been researching for the past three years is perhaps more relevant now than ever: the relationship between the European Community and the Soviet Union. The historian is gathering valuable information on the EC’s early foreign policy and the obstacles that had to be overcome to try to make the Community speak with one voice.
Spotlight on Young Researchers: Eva Lagunas
Eva Lagunas has always been curious about technology, even building her own makeshift smartphone when she was a child. A couple of degrees later, the Spanish national set her sights on coming to Luxembourg, family in tow, to take up a Postdoc position at the University of Luxembourg’s Interdisciplinary Centre for Security, Reliability and Trust (SnT). Now, she feels lucky to spend her time researching satellite communications in the 5G era.
Spotlight on Young Researchers: Laurie Maldonado
Laurie Maldonado’s research focuses on single-parent families. After suddenly becoming a single parent herself, she experienced first-hand how quickly single-parent families can fall into poverty in the United States, not knowing if she could continue her research. Then Laurie secured an AFR PhD grant, conducting her research at the LIS Cross-National Data Center in Luxembourg and at UCLA. A few years and a successful PhD defence later, we talked with Laurie about her journey and her close-to-home research.
Spotlight on Young Researchers: Sumit Gautam
While we frequently hear about new trends in mobile and wireless technologies, challenges remain, such as the need to charge devices on a stationary device. At the SnT at the University of Luxembourg, Postdoc Sumit Gautam works on solving the future information and energy requirements of wireless devices, via radio frequency (RF)-based techniques.
Spotlight on Young Researchers: Are you what you eat?
Cardiometabolic complications threaten health and reduce life expectancy. In Luxembourg, 1 in 3 people have metabolic syndrome, as a risk factor for cardiometabolic complications such as obesity, high blood sugar and cholesterol, as well as hypertension. Science has shown a link between what we eat and our health – nutritionists are now investigating how dietary strategies could prevent these health complications.