Spotlight on Young Researchers: Charles de Bourcy

 

Charles de Bourcy decided to become a researcher on human health when he realised the human body is not invincible. After completing his undergraduate studies at University of Oxford, the Luxembourg national secured one of the most prestigious scholarships in the world and embarked on a PhD at Stanford University. Now in the final year of this PhD in Applied Physics, Charles is taking his first steps towards his goal of building technologies to help ease the burden of global disease.

Charles de Bourcy’s job in his PhD has been to try to find aspects of the human immune system that can be engineered to prevent or treat life-threatening diseases.

“My PhD projects focus on how immune cells can go wrong in old age, how they can be affected by immunotherapy for systemic sclerosis, and how we might prevent cancer-fighting cells from falling into a dysfunctional ‘exhausted’ state”, Charles explains.

Charles adds that this involves using the latest advances in genomics technology, combined with high-performance computing and quantitative analytics.

“Early on, a lot of time might be spent preparing blood samples for DNA sequencing, which means pipetting reagents. Later on, I spend most of my time coding to carry out computational analysis. In the afternoons, I often meet with the collaborators to discuss progress or learn about advances from other research groups. In the final phase of a project, I spend my days writing and preparing figures for publication.”

“I was drawn to the profound impact a researcher can have”

Charles explains his passion for research was triggered by the realisation that the human body is not invincible – that there are infectious diseases, cancers, autoimmune diseases and more that still have extremely limited treatment options.

“This feeling of helplessness pushed me to work on problems in human health. I was drawn to the profound impact the work of a researcher can have: a single discovery can change the paradigm for how an entire class of diseases are handled.

“For example, synthetic biology has enabled engineered immune cells against tumors, which have the potential to improve outcomes for a whole range of different cancers.

“Part of the fun is that such breakthroughs often happen in indirect ways — there’s this saying that the light bulb wasn’t invented by someone trying to make a better candle.”

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable”

In terms of what Charles wants to achieve as a scientist, he explains that he wants to help reduce the global disease burden, by building technologies that enable diseases to be treated – or prevented – in the best possible way:

“My first step in this endeavor has been to develop tools that allow previously impenetrable aspects of immunology to be measured quantitatively.

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable – advances in genomics, image processing and machine learning could be used to great effect in medicine, particularly if leveraged at a large scale.

“For example, surveys of immune repertoires and viral evolution across the globe could lead to more efficacious vaccine development and allow epidemics to be managed better, before they develop into catastrophic pandemics.”

Charles left Luxembourg for his undergraduate studies at the University of Oxford in the UK, before moving to Stanford University in California for his PhD. Even though Charles has been away for some years, he has been keeping an eye on the research landscape in Luxembourg for his future scientific plans:

“I have been following the development of Luxembourg’s research infrastructure with excitement. The country is pouring a lot of resources into expanding its research activity, making it a very attractive place to launch ambitious projects.”

Charles is now finishing up his PhD in Applied Physics at Stanford University. Charles’ PhD was funded by the International Fulbright Science & Technology Award and by the Melvin and Joan Lane Stanford Graduate Fellowship.

Meeting Nobel Prize winners

Charles was one of 400 early-career scientists selected to attend 2015 Lindau Nobel Laureate Meeting, with his attendance sponsored by the FNR – read an interview with Charles about the experience.

Charles at the 2015 Lindau Nobel Laureate Meeting, here with Françoise Barré-Sinoussi, 2008 recipient of the Nobel Prize in Physiology or Medicine for the discovery of HIV.
Charles de Bourcy

About Spotlight on Young Researchers

Spotlight on Young Researchers is an FNR initiative to highlight early career researchers across the world who have a connection to Luxembourg. This article is the 17th in a series of around 25 articles, which will be published on a weekly basis. You can see more articles below as and when they are published.

Spotlight on Young Researchers: Turning up the heat on solar absorbers

Using solar absorbers for collection and storage of heat from the sun is an environmentally friendly way to generate heat, yet only 16% of heating is generated from renewable energy. Material scientists are looking for ways to boost this number by making the solar absorber coatings more efficient.

Spotlight on Young Researchers: Jose-Luis Sanchez-Lopez

Jose-Luis Sanchez-Lopez works with multirotor aerial robots – drones. Despite being early in his research career, the Spanish national’s research is already taking off, having secured him several awards at international competitions. After completing his PhD in 2017, Jose-Luis set his sights on Luxembourg, where he works as a Postdoc at the SnT at the University of Luxembourg, with the goal of giving drones enough AI that they can safely operate autonomously in a range of environments.

Spotlight on Young Researchers: Sebastian Scheer

Senior Postdoc Sebastian Scheer’s thirst for understanding how biological systems work led him to dive into the world of immunology research. After moving from Germany to Canada, the Luxembourg national got the chance to set up his group leader’s new lab in Australia, where his research revolves around the T cell, a key player in the shaping of immune responses.

Spotlight on Young Researchers: Anna Scaini

Anna Scaini’s appetite for becoming a researcher was stirred at University, stemming from a desire to ‘save’ the last natural river in Europe, which runs close to her home town and causes dangerous local flooding. The Italian national is taking the first step towards pursuing her goal as she prepares to complete her PhD thesis in Hydrology at the Luxembourg Institute of Science and Technology (LIST).

Spotlight on Young Researchers: Yamila Mariel Omar

As part of her Industrial Fellowship – a collaboration between the University of Luxembourg and company Husky – PhD candidate Yamila Mariel Omar helps industry to monetize their proprietary data by means of big data analytics. We speak to the Argentinian national who also became a mother during her PhD.

Spotlight on Young Researchers: László Sándor

For László Sándor research is the ultimate war against ‘fake news’. After completing his PhD in Economics at Harvard, the Hungarian-American national chose a Postdoc position at the Luxembourg School of Finance at the University of Luxembourg, where his work includes big data projects, field experiments in household finance and applied microeconomics.

Spotlight on Young Researchers: Anna Schleimer

In high school, Anna Schleimer thought everything there was to know in science was already known. When she discovered how many unanswered questions there still are, curiosity drove her to become a researcher. The Luxembourg national is now in the 1st year of her AFR PhD, in what is not your most common topic: As a marine biologist, Anna studies fin whales as part of her joint PhD at University of Groningen and University of St Andrews.

Spotlight on Young Researchers: A fully automatic flood mapping algorithm

Flooding presents a major hazard in both rural and urban areas. Luxembourg was also affected by the significant floods that devastated parts of Germany in July 2021. With the goal of predicting areas that will flood, scientists are working on various aspects of flood-mapping using satellite data.

Spotlight on Young Researchers: Pit Ullmann

Pit Ullmann’s interest in natural sciences was piqued in high school. The Luxembourg national went on to study molecular biology at the University of Innsbruck and then found himself desiring a job that would be both interdisciplinary and diversified – fast forward and Pit is now completing his AFR PhD at the University of Luxembourg, where his research group studies why and how colon cancer develops and spreads.

Spotlight on Young Researchers: Steve Dias Da Cruz

While machine learning and deep learning have come a long way, they are not yet at a stage where autonomous vehicles can handle unexpected situations. As part of a public research-industry collaboration, early career researcher Steve Dias Da Cruz investigates possibilities to reduce the amount of data needed to train reliable deep learning models for safety critical applications in the automotive industry.

Spotlight on Young Researchers: Nanotechnology – a future big player in health

Divya Balakrishnan, Dipti Rani and Serena Rollo are women in science working in a field that could have a major impact on how health is managed: In the group of FNR ATTRACT Fellow César Pascual García at the Luxembourg Institute of Science and Technology (LIST), the team works on developing sensors for biochemical applications focusing on medicine.

Spotlight on Young Researchers: Environmental factors and their role in Parkinson’s Disease

An estimated 10% of Parkinson’s Diseases cases are due to genetic factors – in the search for answers as to what could cause the other 90%, research is increasingly finding evidence pointing to environmental factors. To paint a clearer picture of what role chemicals could play in the disease, researchers are for example looking for ‘fingerprints’ of chemicals in biological samples.

Spotlight on Young Researchers: Carole Lara Veiga de Sousa

Why can our bodies defend itself against some diseases but not others? This is something Carole Lara Veiga de Sousa has always been eager to understand. In the framework of her PhD at the Luxembourg Centre for Systems Biomedicine (LCSB) and Luxembourg Institute of Health (LIH), the Portuguese national took at closer look at the microglial cells – immune cells in the central nervous system – and what impact they have on the brain’s ability to fend of infections.

Spotlight on Young Researchers: Ramona Pelich

Ramona Pelich uses data from satellites in space to improve maritime surveillance and flood hazard monitoring. Splitting her time between the Luxembourg Institute of Science and Technology (LIST) and the company LuxSpace as part of her AFR-PPP Postdoc, the Romanian national’s work has already found direct application when flood maps she co-developed were used in the aftermath of destructive 2017 hurricanes Harvey and Irma.

Spotlight on Young Researchers: The role a gene plays in neurodegeneration and cancer

Neurogenerative diseases and cancer affect millions of people worldwide, especially people over 60. While advances in diagnosis and treatment have been made, there are still many open questions on the path to better treatment and earlier diagnosis. Translational neuroscientist Pauline Mencke studies a gene that is involved both in Parkinson’s disease and the brain cancer Glioblastoma multiforme.

Spotlight on Young Researchers: Understanding our immune system

Stemming from Italy, Indonesia, Luxembourg, Portugal and Spain, the members of the Experimental & Molecular Immunology Group truly are an international team. In the group of FNR ATTRACT Fellow Prof Dr Dirk Brenner at the Luxembourg Institute of Health (LIH), the team of young researchers investigates different aspects of the immune system with one common goal: Understanding how our immune system is regulated by different mechanisms – and how this knowledge can be used to combat disease.

Spotlight on Young Researchers: Understanding brain mechanisms behind eating disorders

Eating disorders affect up to 5% of people. At the University of Luxembourg, Dr Annika Lutz and Lynn Erpelding study the brain mechanisms that help form body image, and want to understand how eating disorders develop. Using a multidimensional approach, the team’s ultimate goal is to improve treatment for people suffering from eating disorders, such as anorexia nervosa.

Spotlight on Young Researchers: Dominique Santana

After completing her master’s degree, Luxembourg national Dominique Santana decided to spend time in her mother’s birth country Brazil. While there, she became intrigued by Brazil’s communities of Luxembourgish nationals and wanted to investigate further. Now in the first year of her AFR PhD at the C²DH at the University of Luxembourg, Dominique is examining the paths of Luxembourgers who emigrated to Brazil from 1920 – 1965, which has already rekindled old friendships.

Spotlight on Young Researchers: Improving how industrial plants are engineered

Current engineering systems have an issue: It is fragmented – process, Piping and structural design are carried out by separate teams and involves an error-prone exchange of data. A research collaboration involving public research and industry is tackling this issue by creating a unique central data hub of a plant to which all teams have access, with promising effects on efficiency.

Spotlight on Young Researchers: Towards predicting ageing-related diseases

A rapid increase in both life expectancy and global population size has led to a rise in the prevalence of chronic ageing-associated diseases. Brain and heart age-associated diseases including hypertension, stroke, heart failure, Alzheimer’s and Parkinson’s diseases are leading causes of mortality and disability worldwide. Researchers are working on much-needed ways to predict these diseases.

Spotlight on Young Researchers: Max Hilaire Wolter

During his Bachelor studies in physics and photovoltaics at the University of Luxembourg, Max Hilaire Wolter was exposed to live-action research for the first time. The experience left such a positive impression that Max proactively sought out to return to the same lab for a PhD after completing his Master’s studies abroad. We spoke to the Luxembourg national about why research is fun, solar cells and the importance of science outreach.

Spotlight on Young Researchers: An algorithm to allocate satellite resources

When the first satellite was launched in the 1950s, earth orbit was a lonely place. Since then, more than 11,000 satellites have been launched into space and over 3,000 are still in operation. Estimates suggest an exponential increase in satellites in the next years, creating a challenge for the effective allocation of the needed bandwidth and power. Researchers are developing algorithms to more effectively allocate the resources where and when they are needed.

Spotlight on Young Researchers: Remko Nijzink

Climate change affects vegetation and water resources. In order to understand these changes, scientists use models – an abstract, mathematical representation of an ecological system. The challenge: Making accurate predictions under change, without ‘tuning’ models with data. We speak to Dutch national Remko Nijzink, Postdoc in the group of FNR ATTRACT Fellow Dr. Stan Schymanski at the Luxembourg Institute of Science and Technology (LIST), about his modelling work and the importance of an open science approach.

Spotlight on Young Researchers: Damien Brevers

Postdoc Damien Brevers has a passion for studying self-control abilities in humans. Having spent time in Belgium and the US building expertise in areas including clinical psychology, sport psychology and brain imaging, the Belgian national has just joined the University of Luxembourg and embarked on a project looking at gambling addiction in the age of online betting.

Spotlight on Young Researchers: Paul Hauseux

Paul Hauseux was always interested in science, but only recently settled on the researcher path. Before that, his career ambitions stretched from working in sports or music to teaching science. Some years and a PhD later, the French national has come to Luxembourg for his computational engineering Postdoc in the team of ERC grantee Stéphane Bordas at the University of Luxembourg.

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