Spotlight on Young Researchers: Charles de Bourcy

 

Charles de Bourcy decided to become a researcher on human health when he realised the human body is not invincible. After completing his undergraduate studies at University of Oxford, the Luxembourg national secured one of the most prestigious scholarships in the world and embarked on a PhD at Stanford University. Now in the final year of this PhD in Applied Physics, Charles is taking his first steps towards his goal of building technologies to help ease the burden of global disease.

Charles de Bourcy’s job in his PhD has been to try to find aspects of the human immune system that can be engineered to prevent or treat life-threatening diseases.

“My PhD projects focus on how immune cells can go wrong in old age, how they can be affected by immunotherapy for systemic sclerosis, and how we might prevent cancer-fighting cells from falling into a dysfunctional ‘exhausted’ state”, Charles explains.

Charles adds that this involves using the latest advances in genomics technology, combined with high-performance computing and quantitative analytics.

“Early on, a lot of time might be spent preparing blood samples for DNA sequencing, which means pipetting reagents. Later on, I spend most of my time coding to carry out computational analysis. In the afternoons, I often meet with the collaborators to discuss progress or learn about advances from other research groups. In the final phase of a project, I spend my days writing and preparing figures for publication.”

“I was drawn to the profound impact a researcher can have”

Charles explains his passion for research was triggered by the realisation that the human body is not invincible – that there are infectious diseases, cancers, autoimmune diseases and more that still have extremely limited treatment options.

“This feeling of helplessness pushed me to work on problems in human health. I was drawn to the profound impact the work of a researcher can have: a single discovery can change the paradigm for how an entire class of diseases are handled.

“For example, synthetic biology has enabled engineered immune cells against tumors, which have the potential to improve outcomes for a whole range of different cancers.

“Part of the fun is that such breakthroughs often happen in indirect ways — there’s this saying that the light bulb wasn’t invented by someone trying to make a better candle.”

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable”

In terms of what Charles wants to achieve as a scientist, he explains that he wants to help reduce the global disease burden, by building technologies that enable diseases to be treated – or prevented – in the best possible way:

“My first step in this endeavor has been to develop tools that allow previously impenetrable aspects of immunology to be measured quantitatively.

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable – advances in genomics, image processing and machine learning could be used to great effect in medicine, particularly if leveraged at a large scale.

“For example, surveys of immune repertoires and viral evolution across the globe could lead to more efficacious vaccine development and allow epidemics to be managed better, before they develop into catastrophic pandemics.”

Charles left Luxembourg for his undergraduate studies at the University of Oxford in the UK, before moving to Stanford University in California for his PhD. Even though Charles has been away for some years, he has been keeping an eye on the research landscape in Luxembourg for his future scientific plans:

“I have been following the development of Luxembourg’s research infrastructure with excitement. The country is pouring a lot of resources into expanding its research activity, making it a very attractive place to launch ambitious projects.”

Charles is now finishing up his PhD in Applied Physics at Stanford University. Charles’ PhD was funded by the International Fulbright Science & Technology Award and by the Melvin and Joan Lane Stanford Graduate Fellowship.

Meeting Nobel Prize winners

Charles was one of 400 early-career scientists selected to attend 2015 Lindau Nobel Laureate Meeting, with his attendance sponsored by the FNR – read an interview with Charles about the experience.

Charles at the 2015 Lindau Nobel Laureate Meeting, here with Françoise Barré-Sinoussi, 2008 recipient of the Nobel Prize in Physiology or Medicine for the discovery of HIV.
Charles de Bourcy

About Spotlight on Young Researchers

Spotlight on Young Researchers is an FNR initiative to highlight early career researchers across the world who have a connection to Luxembourg. This article is the 17th in a series of around 25 articles, which will be published on a weekly basis. You can see more articles below as and when they are published.

Spotlight on Young Researchers: Remko Nijzink

Climate change affects vegetation and water resources. In order to understand these changes, scientists use models – an abstract, mathematical representation of an ecological system. The challenge: Making accurate predictions under change, without ‘tuning’ models with data. We speak to Dutch national Remko Nijzink, Postdoc in the group of FNR ATTRACT Fellow Dr. Stan Schymanski at the Luxembourg Institute of Science and Technology (LIST), about his modelling work and the importance of an open science approach.

Spotlight on Young Researchers: Kacy Greenhalgh

Kacy Greenhalgh has always had an affectation for medicine and health, and how health can be influenced by dietary habits. During her Master studies, the Luxembourg-American national was introduced to FNR ATTRACT Fellow Paul Wilmes and the ‘gut on a chip’, HuMiX. Fascinated by its potential, and how it could be used to study the relation between diet and health, Kacy’s curiosity led her straight to an AFR PhD at the LCSB at the University of Luxembourg.

Spotlight on Young Researchers: Isabel Z. Martínez

Isabel Z. Martínez has been interested in how policies are put in place and how they affect people’s lives for as long as she can remember. After completing her Masters in Economics, she realised that academia was the ideal way to quench her thirst for analysing large data sets and finding answers to questions addressing people’s well-being and policy decisions. The Swiss-Spanish national has been studying income and wealth inequality in Switzerland for years and has now come to Luxembourg as a Postdoc at LISER to expand her research to the Grand Duchy. We spoke to Isabel about life as a research economist, and how it has already enabled her to travel across the globe, as well as work with some of the foremost researchers in her field.

Spotlight on Young Researchers: Lucas Oesch

Luxembourg is one of many countries experiencing the arrival of asylum seekers and refugees that have been displaced for reasons such as conflicts or instability in their own country. Managing a research team for the first time, CORE Junior PI Lucas Oesch leads the project ‘REFUGOV’ at the University of Luxembourg, which looks at the accommodation of asylum seekers and refugees in cities and camps.

Spotlight on Young Researchers: Léon-Charles Tranchevent

Léon-Charles Tranchevent says he has found the perfect job in being a researcher. Cherishing the freedom and unexpectedness of his line of work, the computational biologist also feels it’s his duty to contribute to the training of the next generation of researchers. The French national has recently begun his AFR Bilateral Postdoc at the Luxembourg Institute of Health in collaboration with Nanyang Technological University (NTU) in Singapore.

Spotlight on Young Researchers – revisited 5 years later: From Luxembourg to Australia

When we wrote about Chetan Arora in the 2017 edition of Spotlight on Young Researchers, he was a Postdoc working in requirements engineering at the SnT, having just completed his PhD. 5 years later, Chetan is on the other side of the world working as a Senior Lecturer and Academic Director for coursework research. We spoke to Chetan about how he is still a “houfreg Lëtzebuerger”, what he is working on now, and why after working both in industry and academia, he found his heart to be in the world of research.

Spotlight on Young Researchers: Ramona Pelich

Ramona Pelich uses data from satellites in space to improve maritime surveillance and flood hazard monitoring. Splitting her time between the Luxembourg Institute of Science and Technology (LIST) and the company LuxSpace as part of her AFR-PPP Postdoc, the Romanian national’s work has already found direct application when flood maps she co-developed were used in the aftermath of destructive 2017 hurricanes Harvey and Irma.

Spotlight on Young Researchers: A gas sensor powered by natural light

Many of the things we furnish our homes and office with emit gases that we are oblivious to inhaling. As eliminating these items from our lives is unrealistic, science wants to understand that which we cannot eliminate, thus more effective sensors are needed. Material scientist Rutuja Bhusari combines materials at nanoscale to create a gas sensor powered by nature.

Spotlight on Young Researchers: Turning up the heat on solar absorbers

Using solar absorbers for collection and storage of heat from the sun is an environmentally friendly way to generate heat, yet only 16% of heating is generated from renewable energy. Material scientists are looking for ways to boost this number by making the solar absorber coatings more efficient.

Spotlight on Young Researchers: Ramping up carbohydrates production

Carbs are all around us: a major constituent in food, they also play a role in many biological processes such as intercellular communication; they are in demand in the pharmaceutical industry, where they are currently used as anticoagulants and in skincare. With the goal of no longer having to rely solely on nature’s production of carbs, scientists have been working on ways to ramp up production. A case for chemistry!

Spotlight on Young Researchers: Max Hilaire Wolter

During his Bachelor studies in physics and photovoltaics at the University of Luxembourg, Max Hilaire Wolter was exposed to live-action research for the first time. The experience left such a positive impression that Max proactively sought out to return to the same lab for a PhD after completing his Master’s studies abroad. We spoke to the Luxembourg national about why research is fun, solar cells and the importance of science outreach.

Spotlight on Young Researchers: Nina Hentzen

Nina Hentzen, an organic chemist working on the chemical synthesis of collagen, is fascinated by research at the interface of chemistry and biology. The Luxembourg national is in the second year of her AFR PhD at ETH Zürich – and has just been selected to attend the renowned 2017 Lindau Nobel Laureate Meeting.

Spotlight on Young Researchers: Sumit Gautam

While we frequently hear about new trends in mobile and wireless technologies, challenges remain, such as the need to charge devices on a stationary device. At the SnT at the University of Luxembourg, Postdoc Sumit Gautam works on solving the future information and energy requirements of wireless devices, via radio frequency (RF)-based techniques.

Spotlight on Young Researchers: Pit Losch

Passion and competitiveness is at the heart of being a researcher for Pit Losch, who describes life in research as a rollercoaster ride. The Luxembourg national, who completed his AFR PhD at the University of Strasbourg, is currently a Postdoc at Max Planck Institute for Coal Research, where he investigates and shapes materials for the future. We spoke to Pit about his life as a scientist.

Spotlight on Young Researchers: German Castignani

After doing his Master’s degree and working in the private sector in Argentina, German Castignani decided to do a research internship in France, which piqued his interest for research. After completing his PhD in wireless networking in France, the Italian-Argentinian national came to Luxembourg, where he added an entrepreneurial perspective to his vehicular telematics research, co-founding the SnT’s first spin-off Motion-S.

Spotlight on Young Researchers: How is scientific quality fostered by research collaboration?

In the last decades, how research is conducted has been profoundly changed by ICT, and there has also been a shift from the ‘sole genius’ towards teamwork and especially interdisciplinarity: Today, millions of researchers worldwide collaborate across organisational, disciplinary, and cultural boundaries, extending the possibilities of new scientific discovery. This, and the associated data, has paved the way for the scientific field Science of Science, where one key question is understanding exactly how scientific quality is fostered by research collaboration.

Spotlight on Young Researchers: Pit Ullmann

Pit Ullmann’s interest in natural sciences was piqued in high school. The Luxembourg national went on to study molecular biology at the University of Innsbruck and then found himself desiring a job that would be both interdisciplinary and diversified – fast forward and Pit is now completing his AFR PhD at the University of Luxembourg, where his research group studies why and how colon cancer develops and spreads.

Spotlight on Young Researchers: Identifying environmental pollutants

Nobody is untouched by environmental chemical pollution, but most are unaware of how they are exposed, what to, and the possible health consequences. With over 350,000 registered chemicals in use, an important first step towards assessing their environmental impacts is to make chemical information more machine-readable and open. Environmental Cheminformatics is on the case.

Spotlight on Young Researchers: The challenge of getting autonomous systems to work together seamlessly

An increasing number of systems are now controlled by artificial intelligence (AI): Autonomous vehicles – such as drones or satellites – can be deployed in difficult to access places and used to gather information in real-time. Autonomous systems can also be used simultaneously and cooperate to reach better performances compared to using only one device – but not without challenges: it is no easy task to programme these entities to behave collectively as we want them to. We speak to computer scientist and researcher Florian Felten about his research in this area and the associated challenges.

Spotlight on Young Researchers: Bella Tsachidou

Excessive use of fertilisers in agriculture has led to nitrogen pollution, and calls for bio substitutes are getting louder. PhD candidate Bella Tsachidou from Luxembourg Institute of Science and Technology (LIST) gathers scientific evidence on the benefits of biogas residues and their suitability as biofertilisers, while providing support for the modification of nitrogen-policies on European and global level.

Spotlight on Young Researchers: Maxime Brami

Archaeologist and trained anthropologist Maxime Brami works on uncovering the origins and spread of agriculture, and has just landed a sought-after Marie Skłodowska-Curie Individual Fellowship. We speak to the Luxembourg national about what it’s like to be an archaeologist in academia, the collaborative nature of the field and why archaeologists have a certain responsibility.

Spotlight on Young Researchers: Understanding brain mechanisms behind eating disorders

Eating disorders affect up to 5% of people. At the University of Luxembourg, Dr Annika Lutz and Lynn Erpelding study the brain mechanisms that help form body image, and want to understand how eating disorders develop. Using a multidimensional approach, the team’s ultimate goal is to improve treatment for people suffering from eating disorders, such as anorexia nervosa.

Spotlight on Young Researchers: Maciej Piotr Chrzanowski

Maciej Piotr Chrzanowski never thought he would become a researcher, but a successful attempt at applying for a PhD changed all of that, and the Polish national found himself moving to Luxembourg. Now in the 3rd year of his AFR-PPP PhD, Maciej is embedded both at the University of Luxembourg and in R&D Application Department of steel manufacturing corporation ArcelorMittal, where he works on development of new solutions for structures.

Spotlight on Young Researchers: Dark patterns and the battle to free the web from manipulation

Online services are designed to offer great user experiences and accommodate our needs. They can also use manipulative design strategies to push us to disclose our personal information, purchase goods and subscriptions or spend an excessive quantity of time on apps and games. Learn about ‘dark patterns’ and an interdisciplinary research effort to free the web from manipulation.

Spotlight on Young Researchers: Anjali Sharma

In school, we are taught three states of matter: solid, liquid and gas. The focus of University of Luxembourg PhD candidate Anjali Sharma’s research lies between solid and liquid: liquid crystal. She studies them in unusual shapes that are no larger than the width of a human hair, yet they are considered as large by the scientists of the field. As part of her research, the Indian national got an opportunity for a rare experiment: Taking her research into a zero gravity environment.

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