Spotlight on Young Researchers: Charles de Bourcy

 

Charles de Bourcy decided to become a researcher on human health when he realised the human body is not invincible. After completing his undergraduate studies at University of Oxford, the Luxembourg national secured one of the most prestigious scholarships in the world and embarked on a PhD at Stanford University. Now in the final year of this PhD in Applied Physics, Charles is taking his first steps towards his goal of building technologies to help ease the burden of global disease.

Charles de Bourcy’s job in his PhD has been to try to find aspects of the human immune system that can be engineered to prevent or treat life-threatening diseases.

“My PhD projects focus on how immune cells can go wrong in old age, how they can be affected by immunotherapy for systemic sclerosis, and how we might prevent cancer-fighting cells from falling into a dysfunctional ‘exhausted’ state”, Charles explains.

Charles adds that this involves using the latest advances in genomics technology, combined with high-performance computing and quantitative analytics.

“Early on, a lot of time might be spent preparing blood samples for DNA sequencing, which means pipetting reagents. Later on, I spend most of my time coding to carry out computational analysis. In the afternoons, I often meet with the collaborators to discuss progress or learn about advances from other research groups. In the final phase of a project, I spend my days writing and preparing figures for publication.”

“I was drawn to the profound impact a researcher can have”

Charles explains his passion for research was triggered by the realisation that the human body is not invincible – that there are infectious diseases, cancers, autoimmune diseases and more that still have extremely limited treatment options.

“This feeling of helplessness pushed me to work on problems in human health. I was drawn to the profound impact the work of a researcher can have: a single discovery can change the paradigm for how an entire class of diseases are handled.

“For example, synthetic biology has enabled engineered immune cells against tumors, which have the potential to improve outcomes for a whole range of different cancers.

“Part of the fun is that such breakthroughs often happen in indirect ways — there’s this saying that the light bulb wasn’t invented by someone trying to make a better candle.”

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable”

In terms of what Charles wants to achieve as a scientist, he explains that he wants to help reduce the global disease burden, by building technologies that enable diseases to be treated – or prevented – in the best possible way:

“My first step in this endeavor has been to develop tools that allow previously impenetrable aspects of immunology to be measured quantitatively.

“If more of the technological breakthroughs of the last 50 years can find their way into medicine, a lot more diseases are bound to become tractable – advances in genomics, image processing and machine learning could be used to great effect in medicine, particularly if leveraged at a large scale.

“For example, surveys of immune repertoires and viral evolution across the globe could lead to more efficacious vaccine development and allow epidemics to be managed better, before they develop into catastrophic pandemics.”

Charles left Luxembourg for his undergraduate studies at the University of Oxford in the UK, before moving to Stanford University in California for his PhD. Even though Charles has been away for some years, he has been keeping an eye on the research landscape in Luxembourg for his future scientific plans:

“I have been following the development of Luxembourg’s research infrastructure with excitement. The country is pouring a lot of resources into expanding its research activity, making it a very attractive place to launch ambitious projects.”

Charles is now finishing up his PhD in Applied Physics at Stanford University. Charles’ PhD was funded by the International Fulbright Science & Technology Award and by the Melvin and Joan Lane Stanford Graduate Fellowship.

Meeting Nobel Prize winners

Charles was one of 400 early-career scientists selected to attend 2015 Lindau Nobel Laureate Meeting, with his attendance sponsored by the FNR – read an interview with Charles about the experience.

Charles at the 2015 Lindau Nobel Laureate Meeting, here with Françoise Barré-Sinoussi, 2008 recipient of the Nobel Prize in Physiology or Medicine for the discovery of HIV.
Charles de Bourcy

About Spotlight on Young Researchers

Spotlight on Young Researchers is an FNR initiative to highlight early career researchers across the world who have a connection to Luxembourg. This article is the 17th in a series of around 25 articles, which will be published on a weekly basis. You can see more articles below as and when they are published.

Spotlight on Young Researchers: The hidden half of plants

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Spotlight on Young Researchers: Shedding light on female writers in Luxembourg

Always has literature played a major role in the construction of any national identity – yet, Luxembourgish literature is very little known. Researchers are exploring the country’s literary identity, from a Francophone and a gendered perspective, with a particular focus on female writers.

Spotlight on Young Researchers: Nathasia Mudiwa Muwanigwa

Growing up in Botswana and Zimbabwe, Nathasia Mudiwa Muwanigwa did not see science as a career option. Fast forward a few years: Nathasia is studying Parkinson’s disease as part of her PhD at the LCSB at the University of Luxembourg, and has co-founded a STEM initiative that was featured in Forbes.

Spotlight on Young Researchers: Dark patterns and the battle to free the web from manipulation

Online services are designed to offer great user experiences and accommodate our needs. They can also use manipulative design strategies to push us to disclose our personal information, purchase goods and subscriptions or spend an excessive quantity of time on apps and games. Learn about ‘dark patterns’ and an interdisciplinary research effort to free the web from manipulation.

Spotlight on Young Researchers: Eva Lagunas

Eva Lagunas has always been curious about technology, even building her own makeshift smartphone when she was a child. A couple of degrees later, the Spanish national set her sights on coming to Luxembourg, family in tow, to take up a Postdoc position at the University of Luxembourg’s Interdisciplinary Centre for Security, Reliability and Trust (SnT). Now, she feels lucky to spend her time researching satellite communications in the 5G era.

Overcoming antiquated ideas about history

To many, the Middle Ages are synonymous with the term the ‘Dark Ages’ – a time of decline. The term was coined hundreds of years ago by the era referring to itself as the ‘Renaissance’ – a rebirth of norms and standards. There is in fact much more to the complexity of the Middle Ages and historians are working on overcoming these antiquated ideas. For this research, Dr Christa Birkel won a 2021 FNR Award in the category ‘Outstanding PhD Thesis’.

Spotlight on Young Researchers: Paul Johanns

Paul Johanns works in a research field one does not read about every day: knots. As part of his AFR PhD at the École polytechnique fédérale de Lausanne (EPFL), the Luxembourg national combines high-precision model experiments, computation and theory to untangle the influence of topology on the mechanics of complex knots, particularly those used in surgical procedures.

Spotlight on Young Researchers: Guillaume Nataf

“Would matter be perfect, it would be boring” says Guillaume Nataf, who has an oozing passion for physics and teaching fundamental science. The French national did his PhD in the group of FNR PEARL Chair Jens Kreisel at the Luxembourg Institute of Science and Technology (LIST), in collaboration with the French Atomic Commission (CEA). We spoke to Guillaume, who has just started a Postdoc at the University of Cambridge, about life as a researcher.

Spotlight on Young Researchers: Xianqing Mao

Xianqing Mao comes from a family of professors and doctors and thus has always had a natural interest in science. The Chinese national completed a medical degree, but felt she still had unanswered questions, so she decided to go abroad and took a leap into biomedical research. After stays in France, the UK, the United States and Belgium, Xianqing is now transitioning from junior to senior researcher at the Luxembourg Institute of Health, where she has already been involved in several projects investigating cancer progression.

Spotlight on Young Researchers: Improving how industrial plants are engineered

Current engineering systems have an issue: It is fragmented – process, Piping and structural design are carried out by separate teams and involves an error-prone exchange of data. A research collaboration involving public research and industry is tackling this issue by creating a unique central data hub of a plant to which all teams have access, with promising effects on efficiency.

Spotlight on Young Researchers: The role a gene plays in neurodegeneration and cancer

Neurogenerative diseases and cancer affect millions of people worldwide, especially people over 60. While advances in diagnosis and treatment have been made, there are still many open questions on the path to better treatment and earlier diagnosis. Translational neuroscientist Pauline Mencke studies a gene that is involved both in Parkinson’s disease and the brain cancer Glioblastoma multiforme.

Spotlight on Young Researchers: Hameeda Jagalur Basheer

While solar panels appear on more and more rooftops, researchers are still developing ways to boost their efficiency. As part of her PhD at the Luxembourg Institute of Science and Technology (LIST), Indian national Hameeda Jagalur Basheer is developing alternative materials that can help capture the sunlight better and improve efficiency of solar panels.

Spotlight on Young Researchers: An algorithm to allocate satellite resources

When the first satellite was launched in the 1950s, earth orbit was a lonely place. Since then, more than 11,000 satellites have been launched into space and over 3,000 are still in operation. Estimates suggest an exponential increase in satellites in the next years, creating a challenge for the effective allocation of the needed bandwidth and power. Researchers are developing algorithms to more effectively allocate the resources where and when they are needed.

Spotlight on Young Researchers: Pier Mario Lupinu

When one thinks of banks and financial institutions, the word ‘research’ may not come to mind. However, research has much to offer these institutions, for example new tools to help with delivering critical services. As part of his PhD at the University of Luxembourg, Italian national Pier Mario Lupinu researches issues related to post-resolution in banking and finance.

Spotlight on Young Researchers: Pit Losch

Passion and competitiveness is at the heart of being a researcher for Pit Losch, who describes life in research as a rollercoaster ride. The Luxembourg national, who completed his AFR PhD at the University of Strasbourg, is currently a Postdoc at Max Planck Institute for Coal Research, where he investigates and shapes materials for the future. We spoke to Pit about his life as a scientist.

Spotlight on Young Researchers: Max Hilaire Wolter

During his Bachelor studies in physics and photovoltaics at the University of Luxembourg, Max Hilaire Wolter was exposed to live-action research for the first time. The experience left such a positive impression that Max proactively sought out to return to the same lab for a PhD after completing his Master’s studies abroad. We spoke to the Luxembourg national about why research is fun, solar cells and the importance of science outreach.

Spotlight on Young Researchers: Dimitra Anastasiou

In 2015, Dimitra Anastasiou was featured in our campaign ‘Spotlight on Young Researchers’, which highlighted early-career researchers with a connection to Luxembourg. In November 2015, Dimitra moved to Luxembourg with her young family to start her prestigious Marie Curie Individual Fellowship at the Luxembourg Institute of Science and Technology (LIST). One year on, we caught up with Dimitra!

Spotlight on Young Researchers: Nina Hentzen

Nina Hentzen, an organic chemist working on the chemical synthesis of collagen, is fascinated by research at the interface of chemistry and biology. The Luxembourg national is in the second year of her AFR PhD at ETH Zürich – and has just been selected to attend the renowned 2017 Lindau Nobel Laureate Meeting.

Spotlight on Young Researchers: Sebastian Scheer

Senior Postdoc Sebastian Scheer’s thirst for understanding how biological systems work led him to dive into the world of immunology research. After moving from Germany to Canada, the Luxembourg national got the chance to set up his group leader’s new lab in Australia, where his research revolves around the T cell, a key player in the shaping of immune responses.

Spotlight on Young Researchers: Measuring the environmental impact of investment funds

Sustainable capital market investments are expected to reach 53 trillion USD – about 1 in every 3 dollars invested – by 2025. Meanwhile, a much lower level of funds are going directly into climate-related projects, leading to an increasing concern of greenwashing in the market. Researchers are developing science-based tools to measure the environmental impact of financial investment decisions.

Spotlight on Young Researchers: Lucas Oesch

Luxembourg is one of many countries experiencing the arrival of asylum seekers and refugees that have been displaced for reasons such as conflicts or instability in their own country. Managing a research team for the first time, CORE Junior PI Lucas Oesch leads the project ‘REFUGOV’ at the University of Luxembourg, which looks at the accommodation of asylum seekers and refugees in cities and camps.

Spotlight on Young Researchers: Martin Řehoř

In industry, computer simulations and optimizations are established approaches to inform and improve engineering designs. As part of his Industrial Fellowship, Postdoc Martin Řehoř works on numerical solvers that could help solve design problems that involve the processing of fluids.

Spotlight on Young Researchers: Alex Gansen

Alex Gansen first dabbled in research during his Masters studies in physics at the University of Fribourg (Switzerland), and then decided he wanted to take on the challenge of a PhD, so the Luxembourg national returned to his home country. Alex has just submitted his thesis at the end of the 4th year of his AFR PhD in computational electromagnetics at the Luxembourg Institute of Science and Technology (LIST) in collaboration with the College of Engineering in Swansea. He sees the close links between local industry and research in Luxembourg as a great advantage for the future of research in the Grand Duchy.

Spotlight on Young Researchers: Multiple nationalities, one goal

What do a French, a Spanish, a Brazilian and an Algerian researcher have in common? In the case of Adeline Boileau, Antonio Salgado Somoza, Clarissa P. C. Gomes and Torkia Lalem, it’s that they are all early-career researchers who came to Luxembourg to join forces in the Cardiovascular Research Unit (CVRU) at the Luxembourg Institute of Health (LIH), which aims to identify new personalised strategies to diagnose and treat cardiovascular disease.

Spotlight on Young Researchers: Thomas Elliot

When Thomas Elliot (Tom) cycled from Indonesia to London, he witnessed many people living in hardship. Motivated to research how consumption affects social and environmental justice in a bid to help reduce the hardship witnessed, the New Zealand national applied for an open PhD position at the Luxembourg Institute of Science and Technology (LIST), where he now works on a project that fuses urban metabolism and ecosystem services.

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