Megakines – novel tools for structural insight into receptor:chemokine complexes

SCHEME: Proof-of-Concept

CALL: 2019

DOMAIN: BM - Life Sciences, Biology and Medicine

FIRST NAME: Andy

LAST NAME: Chevigne

INDUSTRY PARTNERSHIP / PPP:

INDUSTRY / PPP PARTNER:

HOST INSTITUTION: LIH

KEYWORDS: Chemokines, Drug discovery, GPCRs, Cryo-EM, Pharmacology, Next-generation structural chaperones, Structural biology, Protein engineering

START: 2020-01-01

END: 2021-12-31

WEBSITE: http://www.lih.lu

Submitted Abstract

We aim to provide the proof of concept for a novel generic tool to facilitate structural studies of chemokine receptors. The proposed technology has the potential to revolutionize structural studies of chemokine receptors which are therapeutic targets for the pharmaceutical industry.

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